PPP2CB and TLX1

Number of citations of the paper that reports this interaction (PMID 9009195)
30

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		PPP2CB	TLX1
Gene Name		protein phosphatase 2, catalytic subunit, beta isozyme	T-cell leukemia homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Cytosol Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding	Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Protein Dephosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic	Central Nervous System Development Positive Regulation Of Cell Proliferation Neuron Differentiation Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Organ Formation
Pathways		Signaling by GPCR Integration of energy metabolism Signaling by FGFR in disease Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Mitotic G1-G1/S phases ERK/MAPK targets Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Spry regulation of FGF signaling Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Signaling by FGFR Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ACP5 AXIN1 C22orf39 DOCK7 GAD1 GSTA1 HK3 LCMT1 MAK MAPT MID1 PACS1 PLXNA3 PRKCB RAF1 RELA RPLP1 SGOL1 TAB1 TAB2 TCTEX1D2 TIPRL TLX1 TRMT61B ZFP28 ZNF775	8 interactors: MEIS1 NFIC PKNOX1 PPP1CB PPP1CC PPP2CA PPP2CB TLE1
Entrez ID		5516	3195
HPRD ID		01487	01728
Ensembl ID		ENSG00000104695	ENSG00000107807
Uniprot IDs		P62714	P31314
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Positive Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway MAPK Cascade Immune Response-regulating Signaling Pathway JNK Cascade Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of MAPK Cascade Pattern Recognition Receptor Signaling Pathway Organ Development Innate Immune Response-activating Signal Transduction Anatomical Structure Morphogenesis Antigen Receptor-mediated Signaling Pathway Regulation Of Metabolic Process Activation Of MAPK Activity Activation Of Innate Immune Response Regulation Of Phosphorus Metabolic Process Generation Of Neurons Positive Regulation Of Protein Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Neuron Differentiation Cytoskeleton Organization	Protein Dephosphorylation Regulation Of Gene Expression Dephosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Triglyceride Catabolic Process Cellular Response To Growth Factor Stimulus Photoperiodism Entrainment Of Circadian Clock Response To Growth Factor Acylglycerol Catabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Circadian Rhythm Triglyceride Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Energy Reserve Metabolic Process Positive Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Circadian Rhythm Regulation Of Signaling Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus RNA Metabolic Process Catabolic Process Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Glycogen Catabolic Process Positive Regulation Of Metabolic Process Gene Expression
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Tagcloud (Difference) ?			anlage asplenia attributable circulation conditional cre creer crossed descendants engineered erythrocytes extramedullary governing hematopoiesis immunological knock lineage manipulation mesenchymal mesenchyme microenvironment niche recapitulates serves spleen t2 tamoxifen tracing venus
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