RNF125 and UBE2U

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		RNF125	UBE2U
Description		ring finger protein 125	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Membrane VCP-NPL4-UFD1 AAA ATPase Complex Intracellular Membrane-bounded Organelle	HULC Complex
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Negative regulators of DDX58/IFIH1 signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Severe bacterial meningitis ( 31092817)
Interacting Genes		26 interacting genes: BHLHA9 CHFR EFHC1 FNDC11 MAVS MYOZ3 PCGF1 PML PNMA6A RIGI SPAG8 TP53 TRIM14 TRIM46 UBC UBE2D1 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2N UBE2U UBE2W USP2 ZNF414	69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		54941	148581
HPRD ID		11500	14599
Ensembl ID		ENSG00000101695	ENSG00000177414
Uniprot IDs		Q96EQ8	A0A0A0MRP4 A0A140VJY9 Q5VVX9
PDB IDs		5DKA 8GBQ 8GCB	1YRV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Proteolysis Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Entrainment Of Circadian Clock By Photoperiod Antiviral Innate Immune Response Catabolic Process Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Defense Response To Virus By Host Nucleotide Binding ATP Binding Transferase Activity Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Defense Response To Virus By Host Regulation Of DNA-templated Transcription Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Regulation Of RNA Biosynthetic Process Defense Response To Virus Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Macromolecule Metabolic Process MRNA Transcription TORC1 Signaling Regulation Of Defense Response To Virus DNA Damage Response Regulation Of RNA Metabolic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Response To Cytokine Stimulus Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Catabolic Process	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing
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