RNF125 and USP2

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		RNF125	USP2
Gene Name		ring finger protein 125, E3 ubiquitin protein ligase	ubiquitin specific peptidase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Centrosome Cell Cortex Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Type I Interferon Production Innate Immune Response	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Regulation Of Proteasomal Protein Catabolic Process
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		17 interactors: CHFR PCGF1 PML TRIM46 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2L6 UBE2N UBE2U UBE2W USP2	67 interactors: APP AURKA BAP1 BEGAIN BEND5 BRCA1 CBLC CCDC136 CCDC36 CCDC57 CCDC85B CCND1 CRY1 DTX3 ERBB2 GOLGA2 HOMER3 HOOK1 HOOK2 IKBKG KIFC3 KRT15 KRT40 LHX4 LNX2 LONRF1 LRSAM1 LZTS2 MAP3K2 MDM2 MNAT1 MTUS2 NDEL1 NEFL NFKB2 PCGF6 PCNA PLA2G2A PNMA1 RAD18 RBCK1 RIPK1 RNF125 RNF126 RNF144B RNF166 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 UBC UBE2S UBOX5 USP21 VPS52
Entrez ID		54941	9099
HPRD ID		11500	05287
Ensembl ID		ENSG00000101695	ENSG00000036672
Uniprot IDs		Q96EQ8	E9PPM2 O75604
PDB IDs			2HD5 2IBI 3NHE 3V6C 3V6E
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein K48-linked Ubiquitination Proteolysis Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 4 Signaling Pathway Cellular Response To Stress Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Mitotic Cell Cycle Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To DNA Damage Stimulus Cellular Response To Oxygen Levels Response To Hypoxia Response To Stress Protein K63-linked Ubiquitination Cellular Metabolic Process Histone Ubiquitination Positive Regulation Of Protein Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Protein Monoubiquitination	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein K63-linked Ubiquitination Protein Metabolic Process Cellular Protein Catabolic Process Defense Response Protein Complex Assembly Regulation Of Viral Release From Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stress Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Trimerization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Autoubiquitination Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of MAP Kinase Activity Regulation Of Cytokine Production Catabolic Process Response To Cytokine Positive Regulation Of MAP Kinase Activity
Tagcloud ?		75a ag aims basel blotting c72 degradation e3 exogenous gst immunoprecipitation interacted interfere interference ip karger ligase mdm2 negatively p53 physically proteasome pull repressed thought transactivation ubiquitin ubiquitinated ubiquitination	accessory alpha2delta beta2 biotinylation cav cav1 channels counteracted counterpart currents de developmentally gated hek inserted ligases nedd4 paramount precipitated recordings remarkably tsa ubiquitylated ubiquitylates ubiquitylating ubiquitylation usps voltage
Tagcloud (Difference) ?		75a ag aims basel blotting c72 degradation e3 exogenous gst immunoprecipitation interacted interfere interference ip karger ligase mdm2 negatively p53 physically proteasome pull repressed thought transactivation ubiquitin ubiquitinated ubiquitination	accessory alpha2delta beta2 biotinylation cav cav1 channels counteracted counterpart currents de developmentally gated hek inserted ligases nedd4 paramount precipitated recordings remarkably tsa ubiquitylated ubiquitylates ubiquitylating ubiquitylation usps voltage
Tagcloud (Intersection) ?