RNF125 and TRIM46

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		RNF125	TRIM46
Gene Name		ring finger protein 125, E3 ubiquitin protein ligase	tripartite motif containing 46
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Intracellular
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity	Zinc Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Type I Interferon Production Innate Immune Response
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		17 interactors: CHFR PCGF1 PML TRIM46 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2L6 UBE2N UBE2U UBE2W USP2	17 interactors: AK5 BRCA1 CBLC MDM4 OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32
Entrez ID		54941	80128
HPRD ID		11500	15563
Ensembl ID		ENSG00000101695	ENSG00000163462
Uniprot IDs		Q96EQ8	B7Z3S2 B7Z4F9 F5GYK0 Q7Z4K8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein K48-linked Ubiquitination Proteolysis Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 4 Signaling Pathway Cellular Response To Stress Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Mitotic Cell Cycle Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To DNA Damage Stimulus Cellular Response To Oxygen Levels Response To Hypoxia Response To Stress Protein K63-linked Ubiquitination Cellular Metabolic Process Histone Ubiquitination Positive Regulation Of Protein Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Protein Monoubiquitination	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Catabolic Process Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cellular Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Cellular Response To Stress DNA Metabolic Process DNA Repair Positive Regulation Of Histone H4-K20 Methylation Fetal Process Involved In Parturition DADP Biosynthetic Process Positive Regulation Of Histone H4-K16 Acetylation Regulation Of DNA Repair Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Metabolic Process G0 To G1 Transition Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Protein K27-linked Deubiquitination Negative Regulation Of SNARE Complex Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Stabilization Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Arrest Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination
Tagcloud ?		75a ag aims basel blotting c72 degradation e3 exogenous gst immunoprecipitation interacted interfere interference ip karger ligase mdm2 negatively p53 physically proteasome pull repressed thought transactivation ubiquitin ubiquitinated ubiquitination	a1cf activins acvr1b acvrl1 ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 ube2q2 urate vegfa
Tagcloud (Difference) ?		75a ag aims basel blotting c72 degradation e3 exogenous gst immunoprecipitation interacted interfere interference ip karger ligase mdm2 negatively p53 physically proteasome pull repressed thought transactivation ubiquitin ubiquitinated ubiquitination	a1cf activins acvr1b acvrl1 ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 ube2q2 urate vegfa
Tagcloud (Intersection) ?