RNF125 and TRIM46

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		RNF125	TRIM46
Description		ring finger protein 125	tripartite motif containing 46
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Membrane VCP-NPL4-UFD1 AAA ATPase Complex Intracellular Membrane-bounded Organelle	Cytoplasm Cytoskeleton Axon Cell Projection Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Regulation Of Protein Localization Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport
Pathways		Negative regulators of DDX58/IFIH1 signaling	Interferon gamma signaling
Drugs
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Serum CC16 levels ( 32839289) Serum uric acid levels ( 30993211) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528 31985003 23263486) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		26 interacting genes: BHLHA9 CHFR EFHC1 FNDC11 MAVS MYOZ3 PCGF1 PML PNMA6A RIGI SPAG8 TP53 TRIM14 TRIM46 UBC UBE2D1 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2N UBE2U UBE2W USP2 ZNF414	20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32
Entrez ID		54941	80128
HPRD ID		11500	15563
Ensembl ID		ENSG00000101695	ENSG00000163462
Uniprot IDs		Q96EQ8	A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8
PDB IDs		5DKA 8GBQ 8GCB
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Proteolysis Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Entrainment Of Circadian Clock By Photoperiod Antiviral Innate Immune Response Catabolic Process Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Defense Response To Virus By Host Nucleotide Binding ATP Binding Transferase Activity Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Defense Response To Virus By Host Regulation Of DNA-templated Transcription Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Regulation Of RNA Biosynthetic Process Defense Response To Virus Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Macromolecule Metabolic Process MRNA Transcription TORC1 Signaling Regulation Of Defense Response To Virus DNA Damage Response Regulation Of RNA Metabolic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Response To Cytokine Stimulus Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Catabolic Process	Post-translational Protein Modification Proteolysis Protein Modification Process Protein Metabolic Process Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cysteine-type Peptidase Activity Protein Ubiquitination Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K27-linked Deubiquitination Ubiquitin-protein Transferase Activity Peptidase Activity Protein Polyubiquitination Regulation Of Signal Transduction Ubiquitin-modified Histone Reader Activity Monoubiquitinated Protein Deubiquitination Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RIG-I Signaling Pathway Regulation Of Cellular Response To Stress Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Repair Negative Regulation Of ERBB Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Stability Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Pyrimidine-containing Compound Biosynthetic Process Positive Regulation Of Error-prone Translesion Synthesis DADP Biosynthetic Process
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