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TERF2IP and CTBP1
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
TERF2IP
CTBP1
Description
TERF2 interacting protein
C-terminal binding protein 1
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Nuclear Body
Shelterin Complex
Nucleus
Nucleoplasm
Cytoplasm
Transcription Repressor Complex
Presynaptic Active Zone Cytoplasmic Component
Glutamatergic Synapse
GABA-ergic Synapse
Molecular Function
Protein Binding
Phosphatase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
Transcription Coregulator Binding
Transcription Corepressor Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Protein Domain Specific Binding
Identical Protein Binding
NAD Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
LncRNA Binding
DNA-binding Transcription Factor Binding
Biological Process
Telomere Maintenance
Negative Regulation Of Protein Phosphorylation
Regulation Of DNA-templated Transcription
Telomere Maintenance Via Telomerase
Regulation Of Double-strand Break Repair Via Homologous Recombination
Telomere Maintenance Via Telomere Lengthening
Telomere Capping
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of DNA Recombination At Telomere
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Localization To Chromosome, Telomeric Region
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Notch Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Viral Genome Replication
Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Synaptic Vesicle Endocytosis
White Fat Cell Differentiation
Regulation Of Cell Cycle
Synaptic Vesicle Clustering
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Deactivation of the beta-catenin transactivating complex
SUMOylation of transcription cofactors
Repression of WNT target genes
Signaling by TCF7L2 mutants
Negative Regulation of CDH1 Gene Transcription
Drugs
Formic acid
Diseases
GWAS
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Smoking status (ever vs never smokers) (
30643258
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Weight (
34074324
)
Type 2 diabetes (
31118516
32499647
)
Interacting Genes
122 interacting genes:
ADA
AIMP2
AK1
AKR1A1
AKR1B10
AKR7A3
AKT1
ANXA5
ANXA8L1
AP2B1
APEX1
ARPP21
BABAM1
BANP
BCL7B
C1orf174
CALML3
CHMP2B
COTL1
CPNE2
CPNE3
CRK
CRYBB1
CRYGS
CTBP1
DBNL
DDX23
DDX24
DDX39A
DNMT3A
DPP3
ENAH
EPAS1
EPS8L1
ETS2
FABP2
GAGE5
GAMT
GNMT
H1-1
H2AC16
H4C2
HAAO
HAGH
HDGFL3
HMGB1
HMGB3
HMGN3
HMGN4
HNRNPK
IDO1
IL1RN
LANCL2
LGALSL
MAGOHB
MCM2
MDH1
MPG
MRTO4
MT1X
MT3
NAIF1
NASP
NOL3
NPSR1
NUDT14
NUDT18
NXNL1
OCM2
OGFR
PABIR1
PACSIN2
PACSIN3
PAFAH1B3
PCNP
PCP4
PEA15
PGLS
PGM1
PIAS1
PML
PNMT
PPP1R2
PPP6R3
PRDX6
PRX
PTEN
PTMA
RABIF
RAD50
RASSF5
RBBP9
RECQL4
RGMA
RIF1
RPAP1
RPP25
S100P
SBDS
SCLY
SCRN2
SET
SNCG
SP100
TALDO1
TBC1D10A
TBCA
TERF2
TMSB10
TMSB4Y
TOR1AIP1
TSSC4
TWF2
UCHL1
VGLL4
WDR5
WIPI2
XAGE2
XPO1
XRCC5
ZNF146
ZNF414
101 interacting genes:
ACTL6B
AKAP9
APC
ARNT2
ATXN1L
BCAS3
BCL3
BMPR2
BRCA1
CBX4
CCDC9
CDC23
CDKN2D
CEP68
CHD3
CPSF7
CREBBP
CRY2
CTBP2
CTNNA1
DCAF6
DGCR6
DMRTB1
EEF1D
ELAC2
ELK3
EP300
FANCC
FANCF
FANCG
FANCL
FOXP1
FUNDC1
GNL3L
GTF2B
H2AX
H3-4
HDAC1
HDAC2
HDAC3
HDAC4
HDAC5
HDAC9
HEMGN
HIC1
HOXB5
HTT
IKZF1
IKZF2
KAT2B
KLF12
LNX1
MAML2
MAPK9
MARCHF10
MECOM
NME2
NOL4
NOL4L
NOS1
NRIP1
NTAQ1
ORC4
PIAS2
PKP2
PLCB1
PNN
PRKAA1
PRKCI
PRPF19
PRPF6
PRRC2B
RAI2
RB1
RBBP5
RBBP8
RBM14
RBM22
RIPK4
RNF111
SART3
SF1
SIN3A
SNRPN
SNW1
SOBP
SPEN
TBP
TCF4
TEAD4
TERF2
TERF2IP
TGIF1
TSHZ3
UNKL
ZBP1
ZEB1
ZEB2
ZFPM2
ZNF219
ZNF750
Entrez ID
54386
1487
HPRD ID
05452
04015
Ensembl ID
ENSG00000166848
ENSG00000159692
Uniprot IDs
Q9NYB0
H0Y8U5
Q13363
X5D8Y5
PDB IDs
1FEX
3K6G
4RQI
7OZ0
8RD4
1MX3
4LCE
4U6Q
4U6S
6CDF
6CDR
6V89
6V8A
7KWM
8ARI
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Protein Binding
Cytosol
Double-stranded Telomeric DNA Binding
Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Chromosome, Telomeric Region
Telomere Organization
Chromatin Remodeling
Protein Domain Specific Binding
Nucleus
Telomere Maintenance
Nucleoplasm
Energy Reserve Metabolic Process
Chromosome Organization
Glycogen Metabolic Process
Alcohol Dehydrogenase (NADP+) Activity
Cellular Detoxification Of Aldehyde
Extracellular Exosome
Telomere Maintenance In Response To DNA Damage
Myelin Maintenance
Negative Regulation Of T-circle Formation
Polysaccharide Metabolic Process
Nucleic Acid Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Maintenance Of Protein Localization In Organelle
DNA Metabolic Process
Plasma Membrane Organization
Quinolinate Biosynthetic Process
Allyl-alcohol Dehydrogenase Activity
DNA Recombination
Helicase Activity
Regulation Of Growth
Generation Of Precursor Metabolites And Energy
Calcium-dependent Phospholipid Binding
Negative Regulation Of DNA Metabolic Process
Cadherin Binding
Regulation Of Cellular Response To Stress
Quinolinate Metabolic Process
Mre11 Complex
Negative Regulation Of Cellular Component Organization
Carbohydrate Metabolic Process
Regulation Of Cell Growth
Actin Monomer Binding
Positive Regulation Of Proteolysis
Maintenance Of Protein Location In Cell
RNA-templated DNA Biosynthetic Process
Nucleoplasm
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Transcription Corepressor Activity
Negative Regulation Of Macromolecule Biosynthetic Process
DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Histone Deacetylase Complex
Chromatin Remodeling
Nuclear Speck
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Chromatin Organization
Negative Regulation Of Metabolic Process
Protein Lysine Deacetylase Activity
Epigenetic Regulation Of Gene Expression
Regulation Of Cell Differentiation
Cellular Response To Stress
Histone Deacetylase Activity
Chromatin Binding
Negative Regulation Of Gene Expression, Epigenetic
Histone Deacetylase Binding
Nucleic Acid Metabolic Process
Transcription Coactivator Activity
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