CTBP1 and PRKAA1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CTBP1	PRKAA1
Description		C-terminal binding protein 1	protein kinase AMP-activated catalytic subunit alpha 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Protein-containing Complex Ciliary Basal Body Neuronal Cell Body
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Notch Signaling Pathway Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Endocytosis White Fat Cell Differentiation Regulation Of Cell Cycle Synaptic Vesicle Clustering	Autophagosome Assembly Response To Hypoxia Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Glucose Metabolic Process Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Lysosome Organization Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Sterol Biosynthetic Process Fatty Acid Oxidation Response To Caffeine SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Stress Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Response To Hydrogen Peroxide Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Protein Localization To Lysosome Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Adipose Tissue Development Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Formic acid	Adenosine phosphate Adenosine phosphate ATP Phenformin Acetylsalicylic acid Fostamatinib Fostamatinib
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Non-cardia gastric cancer ( 26129866 26701879)
Interacting Genes		101 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CCDC9 CDC23 CDKN2D CEP68 CHD3 CPSF7 CREBBP CRY2 CTBP2 CTNNA1 DCAF6 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FUNDC1 GNL3L GTF2B H2AX H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KLF12 LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PKP2 PLCB1 PNN PRKAA1 PRKCI PRPF19 PRPF6 PRRC2B RAI2 RB1 RBBP5 RBBP8 RBM14 RBM22 RIPK4 RNF111 SART3 SF1 SIN3A SNRPN SNW1 SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 TSHZ3 UNKL ZBP1 ZEB1 ZEB2 ZFPM2 ZNF219 ZNF750	72 interacting genes: ABI2 ACACA AGAP2 ATM BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MAGEA3 MAGEA6 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SLC31A1 SRPK2 SSX2IP THAP1 TLE5 TOMM34 TRIM27 TRIM28 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1
Entrez ID		1487	5562
HPRD ID		04015	04115
Ensembl ID		ENSG00000159692	ENSG00000132356
Uniprot IDs		H0Y8U5 Q13363 X5D8Y5	Q13131
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR 6V89 6V8A 7KWM 8ARI	4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone Deacetylase Complex Chromatin Remodeling Nuclear Speck RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Organization Negative Regulation Of Metabolic Process Protein Lysine Deacetylase Activity Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Response To Stress Histone Deacetylase Activity Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Histone Deacetylase Binding Nucleic Acid Metabolic Process Transcription Coactivator Activity	Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Regulation Of Macromolecule Metabolic Process Nucleotide-activated Protein Kinase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Autophagy Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleoplasm Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels AMP-activated Protein Kinase Activity Protein Phosphorylation Cytoplasm Regulation Of Glycolytic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Autophagy Negative Regulation Of Catabolic Process Response To Starvation Protein Binding Protein Modification Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Cycle Cation Binding Response To Nutrient Levels Protein Serine/threonine Phosphatase Activity Negative Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process
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