TERF2IP and MT1X

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF2IP	MT1X
Gene Name		telomeric repeat binding factor 2, interacting protein	metallothionein 1X
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Telomeric DNA Binding	Zinc Ion Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region	Cellular Zinc Ion Homeostasis Nitric Oxide Mediated Signal Transduction Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Zinc Ion
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS			Gambling ( 22780124)
Protein-Protein Interactions		125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414	4 interactors: POT1 TERF1 TERF2IP VKORC1
Entrez ID		54386	4501
HPRD ID		05452	01130
Ensembl ID		ENSG00000166848	ENSG00000187193
Uniprot IDs		Q9NYB0	P80297
PDB IDs		1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Chromosome Organization Negative Regulation Of DNA Biosynthetic Process DNA Replication Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of DNA Replication Regulation Of Organelle Organization Chromosome Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication DNA Metabolic Process Telomeric Loop Formation Telomere Formation Via Telomerase Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Homeostatic Process Protection From Non-homologous End Joining At Telomere Positive Regulation Of Helicase Activity Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Transferase Activity Positive Regulation Of Telomerase Activity Vitamin K Metabolic Process Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Recombination Regulation Of Double-strand Break Repair
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates	annotation cbs degs description devastating diffuse downloaded etiology foundation fpr1 gse idiopathic iips il1r2 interstitial kinds mgam parenchymal played pneumonias ppi profiling s100a12 screened sdr16c5 serpina3 slco4a1 subtypes underscores
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates	annotation cbs degs description devastating diffuse downloaded etiology foundation fpr1 gse idiopathic iips il1r2 interstitial kinds mgam parenchymal played pneumonias ppi profiling s100a12 screened sdr16c5 serpina3 slco4a1 subtypes underscores
Tagcloud (Intersection) ?