CTBP1 and HDAC3

Number of citations of the paper that reports this interaction (PubMedID 11022042)
0

Data Source:
BioGRID (pull down)

		CTBP1	HDAC3
Description		C-terminal binding protein 1	histone deacetylase 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcription Repressor Complex Mitotic Spindle
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding	Transcription Corepressor Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Hydrolase Activity Deacetylase Activity Enzyme Binding Cyclin Binding Chromatin DNA Binding Protein Lysine Deacetylase Activity Histone Deacetylase Binding GTPase Binding NF-kappaB Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Ubiquitin-specific Protease Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Notch Signaling Pathway Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Endocytosis White Fat Cell Differentiation Regulation Of Cell Cycle Synaptic Vesicle Clustering	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation In Utero Embryonic Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription By RNA Polymerase II Protein Deacetylation Regulation Of Mitotic Cell Cycle Epidermis Development Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Myotube Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of TOR Signaling Negative Regulation Of Interleukin-1 Production Negative Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Protein Modification Process Regulation Of Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Protein Export From Nucleus Rhythmic Process Spindle Assembly Random Inactivation Of X Chromosome Neural Precursor Cell Proliferation Establishment Of Skin Barrier Cellular Response To Mechanical Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Fluid Shear Stress Response To Dexamethasone Negative Regulation Of Ferroptosis Positive Regulation Of Cold-induced Thermogenesis DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Ferroptosis Cornified Envelope Assembly Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		Formic acid	Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Phenylbutyric acid Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	Refractive error ( 32231278)
Interacting Genes		101 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CCDC9 CDC23 CDKN2D CEP68 CHD3 CPSF7 CREBBP CRY2 CTBP2 CTNNA1 DCAF6 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FUNDC1 GNL3L GTF2B H2AX H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KLF12 LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PKP2 PLCB1 PNN PRKAA1 PRKCI PRPF19 PRPF6 PRRC2B RAI2 RB1 RBBP5 RBBP8 RBM14 RBM22 RIPK4 RNF111 SART3 SF1 SIN3A SNRPN SNW1 SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 TSHZ3 UNKL ZBP1 ZEB1 ZEB2 ZFPM2 ZNF219 ZNF750	103 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 CUL4B DAXX DHX30 EED ELL EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16
Entrez ID		1487	8841
HPRD ID		04015	08950
Ensembl ID		ENSG00000159692	ENSG00000171720
Uniprot IDs		H0Y8U5 Q13363 X5D8Y5	O15379
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR 6V89 6V8A 7KWM 8ARI	4A69
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone Deacetylase Complex Chromatin Remodeling Nuclear Speck RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Organization Negative Regulation Of Metabolic Process Protein Lysine Deacetylase Activity Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Response To Stress Histone Deacetylase Activity Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Histone Deacetylase Binding Nucleic Acid Metabolic Process Transcription Coactivator Activity	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Histone Deacetylase Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Transcription Repressor Complex Transcription Regulator Complex DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription Chromatin Organization Transcription Coactivator Binding Regulation Of MiRNA Metabolic Process Regulation Of Developmental Process Histone Deacetylase Complex DNA-binding Transcription Factor Activity
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