CTBP1 and KLF12

Number of citations of the paper that reports this interaction (PMID 11373277)
10

Data Source:
HPRD (in vitro, in vivo)

		CTBP1	KLF12
Gene Name		C-terminal binding protein 1	Kruppel-like factor 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Transcriptional Repressor Complex	Nucleus
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Protein Homodimerization Activity NAD Binding Repressing Transcription Factor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Phosphorylation Golgi Organization Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Oxidation-reduction Process Negative Regulation Of Histone H4 Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS			Pancreatic cancer ( 20101243) Phospholipid levels (plasma) ( 22359512) Ventricular conduction ( 21076409)
Protein-Protein Interactions		83 interactors: ACTL6B APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FOXP1 FOXP2 FUNDC1 GTF2B HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HIST3H3 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCOR LCORL LNX1 MAPK9 MARCH10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 ORC4 PIAS2 PLCB1 PNN PRKAA1 RAI2 RB1 RBBP5 RBBP8 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TCF7L2 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219	4 interactors: APP CTBP1 EHMT2 THAP1
Entrez ID		1487	11278
HPRD ID		04015	06336
Ensembl ID		ENSG00000159692	ENSG00000118922
Uniprot IDs		Q13363	Q8WWI3 Q9Y4X4
PDB IDs		1MX3
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Chromosome Organization Positive Regulation Of Metabolic Process Developmental Process Chromatin Modification Embryo Development Transcription From RNA Polymerase II Promoter Anatomical Structure Development Chromatin Organization Histone H4 Deacetylation Regulation Of Cell Differentiation Organelle Organization Organ Development Metabolic Process Regulation Of Cellular Process System Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of Cell Cycle Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury DNA Methylation On Cytosine Within A CG Sequence Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Neuron Remodeling Negative Regulation Of Histone H4 Acetylation Histone H3-K27 Methylation Histone Modification Regulation Of Cellular Amino Acid Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Peptidyl-lysine Dimethylation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Methylation On Cytosine Growth Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Histone H4 Acetylation White Fat Cell Differentiation Endothelial Cell Proliferation Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Deacetylation Histone H3-K9 Methylation Chromatin Modification Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Peptidyl-lysine Acetylation Synaptonemal Complex Assembly Negative Regulation Of Protein Acetylation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Synaptonemal Complex Organization Viral Genome Replication Positive Regulation Of Protein Deacetylation Neuron Maturation
Tagcloud ?		adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate	aberrations arrays caucasian cdkn2a cna cnas copy curative decades deleted discovered driver eac esophageal esophagectomy fhit frequent gistic heterozygosity intent oncogenes ptprd regions residing smad4 snp stratified suitable targetable
Tagcloud (Difference) ?		adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate	aberrations arrays caucasian cdkn2a cna cnas copy curative decades deleted discovered driver eac esophageal esophagectomy fhit frequent gistic heterozygosity intent oncogenes ptprd regions residing smad4 snp stratified suitable targetable
Tagcloud (Intersection) ?