TERF2IP and MDH1

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF2IP	MDH1
Gene Name		telomeric repeat binding factor 2, interacting protein	malate dehydrogenase 1, NAD (soluble)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex	Extracellular Space Cytoplasm Mitochondrion Centrosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Telomeric DNA Binding	Malic Enzyme Activity L-malate Dehydrogenase Activity Diiodophenylpyruvate Reductase Activity NAD Binding
	Biological Process	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process Pathogenesis Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs			NADH Nicotinamide-Adenine-Dinucleotide 2\'-Monophosphoadenosine 5\'-Diphosphoribose
Diseases
GWAS
Protein-Protein Interactions		125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414	7 interactors: EGFR FUS GPD1 MPP3 TERF1 TERF2IP TP53
Entrez ID		54386	4190
HPRD ID		05452	01100
Ensembl ID		ENSG00000166848	ENSG00000014641
Uniprot IDs		Q9NYB0	P40925
PDB IDs		1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds	Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of DNA Replication Regulation Of Telomere Maintenance RNA-dependent DNA Replication Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Cycle Negative Regulation Of DNA Replication Cellular Response To Drug Regulation Of DNA Repair Regulation Of Mitotic Cell Cycle Cell Aging Negative Regulation Of Cell Cycle Telomere Maintenance Response To Osmotic Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Chromosome Organization Alkanesulfonate Metabolic Process Glycerophosphate Shuttle Negative Regulation Of DNA Recombination At Telomere Nucleobase-containing Compound Metabolic Process Response To Drug Regulation Of Fibroblast Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Macromitophagy Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Oligodendrocyte Apoptotic Process Astrocyte Activation Regulation Of Response To DNA Damage Stimulus Response To UV Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Reactive Oxygen Species Metabolic Process Mitochondrial Transport Negative Regulation Of Helicase Activity Telomeric Loop Formation Age-dependent Telomere Shortening Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Circadian Rhythm Positive Regulation Of Protein Complex Assembly Telomere Maintenance Via Telomere Shortening
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Intersection) ?