TERF2IP and PPP1R2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF2IP	PPP1R2
Gene Name		telomeric repeat binding factor 2, interacting protein	protein phosphatase 1, regulatory (inhibitor) subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex
	Molecular Function	Protein Binding Telomeric DNA Binding	Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region	Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414	12 interactors: CDK5 CSNK2A1 CSNK2A2 GSK3B LMTK2 NEK2 PPP1CA PPP1CC PPP1R9A PPP1R9B TERF2IP TINF2
Entrez ID		54386	5504
HPRD ID		05452	03478
Ensembl ID		ENSG00000166848	ENSG00000184203
Uniprot IDs		Q9NYB0	P41236 Q6NXS2
PDB IDs		1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds	Regulation Of Organelle Organization Cell Cycle Negative Regulation Of Chromosome Organization Rhythmic Process Regulation Of Mitotic Nuclear Division Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Cell Cycle Process Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Neuron Development Glycogen Metabolic Process Regulation Of Cell Division Neuron Differentiation Response To External Stimulus Negative Regulation Of Telomere Maintenance Polysaccharide Metabolic Process Regulation Of Chromosome Segregation Cell Projection Organization Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Cell Growth Regulation Of Signaling Peptidyl-serine Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Axon Guidance Cellular Protein Modification Process Regulation Of Telomere Maintenance Regulation Of Mitotic Cell Cycle Energy Reserve Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Protein Metabolic Process Triglyceride Catabolic Process Generation Of Neurons Regulation Of Carbohydrate Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Entrainment Of Circadian Clock By Photoperiod Neurogenesis Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Circadian Rhythm Cell Cycle Process Protein Localization To Chromosome Axonogenesis Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Export From Nucleus Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates	a375 abrogating augmentation benzodiazepines calyculin contrasted dephosphorylates fmk haematological hdac6 hdaci hybridizing hybrids hypophos mechanistically melanin melanocytes offering oxamflatin phorylated pig1 prompted prospects rising saha shuffling timp vad
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates	a375 abrogating augmentation benzodiazepines calyculin contrasted dephosphorylates fmk haematological hdac6 hdaci hybridizing hybrids hypophos mechanistically melanin melanocytes offering oxamflatin phorylated pig1 prompted prospects rising saha shuffling timp vad
Tagcloud (Intersection) ?