CTBP1 and SPEN

Number of citations of the paper that reports this interaction (PubMedID 16287852)
42

Data Source:
BioGRID (pull down)

		CTBP1	SPEN
Description		C-terminal binding protein 1	spen family transcriptional repressor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Nucleus Nucleoplasm Transcription Repressor Complex Extracellular Exosome
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding	Nucleic Acid Binding DNA Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Notch Signaling Pathway Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Endocytosis White Fat Cell Differentiation Regulation Of Cell Cycle Synaptic Vesicle Clustering	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulatory NcRNA-mediated Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Neurogenesis Random Inactivation Of X Chromosome
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	RHOBTB1 GTPase cycle
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591) Hemoglobin levels ( 32327693)
Interacting Genes		101 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CCDC9 CDC23 CDKN2D CEP68 CHD3 CPSF7 CREBBP CRY2 CTBP2 CTNNA1 DCAF6 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FUNDC1 GNL3L GTF2B H2AX H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KLF12 LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PKP2 PLCB1 PNN PRKAA1 PRKCI PRPF19 PRPF6 PRRC2B RAI2 RB1 RBBP5 RBBP8 RBM14 RBM22 RIPK4 RNF111 SART3 SF1 SIN3A SNRPN SNW1 SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 TSHZ3 UNKL ZBP1 ZEB1 ZEB2 ZFPM2 ZNF219 ZNF750	24 interacting genes: ATXN1 CLK1 CRK CTBP1 DLX5 HDAC1 HDAC2 ITCH MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6
Entrez ID		1487	23013
HPRD ID		04015	10230
Ensembl ID		ENSG00000159692	ENSG00000065526
Uniprot IDs		H0Y8U5 Q13363 X5D8Y5	Q96T58
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR 6V89 6V8A 7KWM 8ARI	1OW1 2RT5 4P6Q 7Z1K
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone Deacetylase Complex Chromatin Remodeling Nuclear Speck RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Organization Negative Regulation Of Metabolic Process Protein Lysine Deacetylase Activity Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Response To Stress Histone Deacetylase Activity Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Histone Deacetylase Binding Nucleic Acid Metabolic Process Transcription Coactivator Activity	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Stem Cell Differentiation NuRD Complex Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Cell Population Proliferation Histone Deacetylase Binding Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Protein-containing Complex Regulation Of Cell Differentiation Nucleosomal DNA Binding Histone Deacetylase Complex DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Commitment Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Transcription Cis-regulatory Region Binding Regulation Of Developmental Process Regulation Of MiRNA Transcription Nucleoplasm DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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