CTBP1 and PNN

Number of citations of the paper that reports this interaction (PubMedID 15542832)
65

Data Source:
HPRD (in vitro, in vivo)

		CTBP1	PNN
Description		C-terminal binding protein 1	pinin, desmosome associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Nucleus Nucleoplasm Spliceosomal Complex Intermediate Filament Plasma Membrane Cell-cell Junction Membrane Nuclear Speck Desmosome Exon-exon Junction Complex Anchoring Junction Catalytic Step 2 Spliceosome
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding	DNA Binding RNA Binding Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Notch Signaling Pathway Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Endocytosis White Fat Cell Differentiation Regulation Of Cell Cycle Synaptic Vesicle Clustering	MRNA Splicing, Via Spliceosome MRNA Processing Cell Adhesion RNA Splicing
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	mRNA Splicing - Major Pathway
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)
Interacting Genes		101 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CCDC9 CDC23 CDKN2D CEP68 CHD3 CPSF7 CREBBP CRY2 CTBP2 CTNNA1 DCAF6 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FUNDC1 GNL3L GTF2B H2AX H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KLF12 LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PKP2 PLCB1 PNN PRKAA1 PRKCI PRPF19 PRPF6 PRRC2B RAI2 RB1 RBBP5 RBBP8 RBM14 RBM22 RIPK4 RNF111 SART3 SF1 SIN3A SNRPN SNW1 SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 TSHZ3 UNKL ZBP1 ZEB1 ZEB2 ZFPM2 ZNF219 ZNF750	19 interacting genes: CNGB1 CSNK2A1 CTBP1 CTBP2 DYNC1I2 KRT18 KRT19 KRT27 KRT8 PNISR PPIG PRP4K RBM12B RNPS1 SRRM2 SRSF4 USP7 YWHAG ZCCHC17
Entrez ID		1487	5411
HPRD ID		04015	04401
Ensembl ID		ENSG00000159692	ENSG00000100941
Uniprot IDs		H0Y8U5 Q13363 X5D8Y5	Q9H307
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR 6V89 6V8A 7KWM 8ARI
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone Deacetylase Complex Chromatin Remodeling Nuclear Speck RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Organization Negative Regulation Of Metabolic Process Protein Lysine Deacetylase Activity Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Response To Stress Histone Deacetylase Activity Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Histone Deacetylase Binding Nucleic Acid Metabolic Process Transcription Coactivator Activity	Symbiont-mediated Disruption Of Host Cell PML Body Keratin Filament RNA Binding Nuclear Speck Intermediate Filament RNA Splicing RNA Splicing, Via Transesterification Reactions White Fat Cell Differentiation Hepatocyte Apoptotic Process Cell Periphery Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Viral Genome Replication Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Metabolic Process Nuclear Matrix Negative Regulation Of RNA Splicing NAD Binding Cyclic Nucleotide-activated Monoatomic Ion Channel Activity Olfactory Nerve Maturation Nucleoplasm Negative Regulation Of Translational Initiation Nucleus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transcription Coregulator Binding Transcription Corepressor Binding Epithelial Cell Apoptotic Process Structural Molecule Activity MRNA Processing Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Non-motile Cilium Membrane Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Negative Regulation Of Proteasomal Protein Catabolic Process Transcription Repressor Complex Tumor Necrosis Factor-mediated Signaling Pathway Structural Constituent Of Skin Epidermis RNA Processing TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Alternative MRNA Splicing, Via Spliceosome Nerve Maturation Response To Odorant Protein Kinase CK2 Complex Regulation Of Chromosome Separation Regulation Of Intracellular Transport
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