TERF2IP and MAGOHB

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TERF2IP	MAGOHB
Description		TERF2 interacting protein	mago homolog B, exon junction complex subunit
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Exon-exon Junction Complex Neuronal Cell Body U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	RNA Binding Protein Binding
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Weight ( 34074324)
Interacting Genes		122 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414	74 interacting genes: ADAMTSL4 AMOTL2 BEND7 C18orf54 CALCOCO2 CARD10 CCDC102B CCDC106 CCDC33 CEBPA DVL2 DVL3 EFHC2 FHL5 FXR1 GNPDA2 GOLGA2 GPANK1 HMG20A HSF2BP IHO1 IKZF1 IKZF3 INCA1 KRT40 KRT75 KRTAP1-1 KRTAP13-2 MID2 NDUFB7 PARD6B PAX7 PBX4 PKP2 PRPH PRPSAP1 PTPN21 RBAK RBM8A RBMX REL RUNDC3A SNW1 SPATA6 SPDYE4 STX11 TADA2A TCF4 TERF2 TERF2IP THAP7 TLE5 TRA2A TRA2B TRIM27 TRIM42 YWHAG ZBTB10 ZBTB42 ZFP14 ZFYVE1 ZNF19 ZNF250 ZNF398 ZNF426 ZNF438 ZNF446 ZNF449 ZNF547 ZNF566 ZNF57 ZNF620 ZNF774 ZNF835
Entrez ID		54386	55110
HPRD ID		05452	08544
Ensembl ID		ENSG00000166848	ENSG00000111196
Uniprot IDs		Q9NYB0	F5H6P7 Q96A72
PDB IDs		1FEX 3K6G 4RQI 7OZ0 8RD4	5XJC 5YZG 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?		Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process	Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process Zinc Ion Binding Regulation Of Macromolecule Biosynthetic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of RNA Splicing Identical Protein Binding Intermediate Filament Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Intermediate Filament Organization Regulation Of MRNA Processing Shelterin Complex Protection From Non-homologous End Joining At Telomere Positive Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Positive Regulation Of Neuron Projection Arborization Positive Regulation Of RNA Metabolic Process Nuclear Telomere Cap Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament G-rich Strand Telomeric DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Localization To Chromosome, Telomeric Region Spliceosomal Complex Regulation Of RNA Splicing Telomere Capping Metal Ion Binding Telomere Maintenance In Response To DNA Damage
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