CTBP1 and ZEB2

Number of citations of the paper that reports this interaction (PMID 12714599)
21

Data Source:
HPRD (two hybrid, in vivo)

		CTBP1	ZEB2
Gene Name		C-terminal binding protein 1	zinc finger E-box binding homeobox 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Transcriptional Repressor Complex	Nucleus
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Protein Homodimerization Activity NAD Binding Repressing Transcription Factor Binding	DNA Binding Phosphatase Regulator Activity Metal Ion Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Phosphorylation Golgi Organization Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Oxidation-reduction Process Negative Regulation Of Histone H4 Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Somitogenesis Neural Tube Closure Transcription, DNA-templated Nervous System Development Hippocampus Development Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Melanocyte Migration Regulation Of Melanosome Organization
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS			Epilepsy (generalized) ( 22949513) Obesity-related traits ( 23251661) Renal cell carcinoma ( 23184150)
Protein-Protein Interactions		83 interactors: ACTL6B APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FOXP1 FOXP2 FUNDC1 GTF2B HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HIST3H3 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCOR LCORL LNX1 MAPK9 MARCH10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 ORC4 PIAS2 PLCB1 PNN PRKAA1 RAI2 RB1 RBBP5 RBBP8 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TCF7L2 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219	11 interactors: APP CBX4 COPS6 CTBP1 CTBP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I
Entrez ID		1487	9839
HPRD ID		04015	05780
Ensembl ID		ENSG00000159692	ENSG00000169554
Uniprot IDs		Q13363	O60315
PDB IDs		1MX3	2DA7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Chromosome Organization Positive Regulation Of Metabolic Process Developmental Process Chromatin Modification Embryo Development Transcription From RNA Polymerase II Promoter Anatomical Structure Development Chromatin Organization Histone H4 Deacetylation Regulation Of Cell Differentiation Organelle Organization Organ Development Metabolic Process Regulation Of Cellular Process System Development	Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Pattern Specification Production Of MiRNAs Involved In Gene Silencing By MiRNA Kidney Development Renal System Development Regulation Of Transcription, DNA-templated Urogenital System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Regulation Of RNA Metabolic Process Cellular Response To DsRNA RNA Metabolic Process Cellular Protein Modification Process Posttranscriptional Gene Silencing Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Gene Expression Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Osteoblast Fate Commitment Mullerian Duct Regression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Viral Process Skeletal System Development Gene Silencing By RNA Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Binding Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate	17q12 3d acinar acquisition amplicon anoikis coamplified disrupted emt enhances epithelial erbb2 escape foxc2 inducing mammary mcf10a mesenchymal overexpression polarity proliferative rara slug steps transformation transition tumorigenesis tumorigenic zeb1
Tagcloud (Difference) ?		adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate	17q12 3d acinar acquisition amplicon anoikis coamplified disrupted emt enhances epithelial erbb2 escape foxc2 inducing mammary mcf10a mesenchymal overexpression polarity proliferative rara slug steps transformation transition tumorigenesis tumorigenic zeb1
Tagcloud (Intersection) ?