TERF2IP and AKR7A3

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF2IP	AKR7A3
Gene Name		telomeric repeat binding factor 2, interacting protein	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Telomeric DNA Binding	Aldo-keto Reductase (NADP) Activity Electron Carrier Activity
	Biological Process	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region	Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Aflatoxin activation and detoxification Biological oxidations Metabolic disorders of biological oxidation enzymes Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS
Protein-Protein Interactions		125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414	2 interactors: AKR7A2 TERF2IP
Entrez ID		54386	22977
HPRD ID		05452	07089
Ensembl ID		ENSG00000166848
Uniprot IDs		Q9NYB0	O95154
PDB IDs		1FEX 3K6G	2CLP
Enriched GO Terms of Interacting Partners?		Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds	Negative Regulation Of DNA Recombination At Telomere Protection From Non-homologous End Joining At Telomere Protein Localization To Chromosome, Telomeric Region Telomere Capping Daunorubicin Metabolic Process Doxorubicin Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Double-strand Break Repair Via Homologous Recombination Glycoside Metabolic Process Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Quinone Metabolic Process Regulation Of DNA Repair Regulation Of DNA Recombination Cellular Aldehyde Metabolic Process Telomere Maintenance Cellular Ketone Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Response To DNA Damage Stimulus Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates	abcb4 anabolic bioassay built carcinogenic carcinogenicity carcinogens ccng1 cdkn1a dataset datasets employs formally gates generalizable informative integrates mathematical methodologies nongenotoxic omics phlda3 rankings reproducible rodent signatures subsamplings toxicogenomics virtue
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates	abcb4 anabolic bioassay built carcinogenic carcinogenicity carcinogens ccng1 cdkn1a dataset datasets employs formally gates generalizable informative integrates mathematical methodologies nongenotoxic omics phlda3 rankings reproducible rodent signatures subsamplings toxicogenomics virtue
Tagcloud (Intersection) ?