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TERF2IP and HMGN3
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
TERF2IP
HMGN3
Description
TERF2 interacting protein
high mobility group nucleosomal binding domain 3
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Nuclear Body
Shelterin Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Protein Binding
Phosphatase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
DNA Binding
Chromatin Binding
Protein Binding
Nucleosomal DNA Binding
Nuclear Thyroid Hormone Receptor Binding
Biological Process
Telomere Maintenance
Negative Regulation Of Protein Phosphorylation
Regulation Of DNA-templated Transcription
Telomere Maintenance Via Telomerase
Regulation Of Double-strand Break Repair Via Homologous Recombination
Telomere Maintenance Via Telomere Lengthening
Telomere Capping
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of DNA Recombination At Telomere
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Localization To Chromosome, Telomeric Region
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Chromatin Organization
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Smoking status (ever vs never smokers) (
30643258
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Weight (
34074324
)
Glucose homeostasis traits (
25524916
)
LDL cholesterol levels x loop diuretics use interaction (
31806883
)
Interacting Genes
122 interacting genes:
ADA
AIMP2
AK1
AKR1A1
AKR1B10
AKR7A3
AKT1
ANXA5
ANXA8L1
AP2B1
APEX1
ARPP21
BABAM1
BANP
BCL7B
C1orf174
CALML3
CHMP2B
COTL1
CPNE2
CPNE3
CRK
CRYBB1
CRYGS
CTBP1
DBNL
DDX23
DDX24
DDX39A
DNMT3A
DPP3
ENAH
EPAS1
EPS8L1
ETS2
FABP2
GAGE5
GAMT
GNMT
H1-1
H2AC16
H4C2
HAAO
HAGH
HDGFL3
HMGB1
HMGB3
HMGN3
HMGN4
HNRNPK
IDO1
IL1RN
LANCL2
LGALSL
MAGOHB
MCM2
MDH1
MPG
MRTO4
MT1X
MT3
NAIF1
NASP
NOL3
NPSR1
NUDT14
NUDT18
NXNL1
OCM2
OGFR
PABIR1
PACSIN2
PACSIN3
PAFAH1B3
PCNP
PCP4
PEA15
PGLS
PGM1
PIAS1
PML
PNMT
PPP1R2
PPP6R3
PRDX6
PRX
PTEN
PTMA
RABIF
RAD50
RASSF5
RBBP9
RECQL4
RGMA
RIF1
RPAP1
RPP25
S100P
SBDS
SCLY
SCRN2
SET
SNCG
SP100
TALDO1
TBC1D10A
TBCA
TERF2
TMSB10
TMSB4Y
TOR1AIP1
TSSC4
TWF2
UCHL1
VGLL4
WDR5
WIPI2
XAGE2
XPO1
XRCC5
ZNF146
ZNF414
7 interacting genes:
SRPK1
SRPK2
TERF1
TERF2
TERF2IP
THRB
VDR
Entrez ID
54386
9324
HPRD ID
05452
16062
Ensembl ID
ENSG00000166848
ENSG00000118418
Uniprot IDs
Q9NYB0
A0A087WZE9
A0A994J3W4
A0A9L9PXC9
Q15651
PDB IDs
1FEX
3K6G
4RQI
7OZ0
8RD4
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Protein Binding
Cytosol
Double-stranded Telomeric DNA Binding
Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Chromosome, Telomeric Region
Telomere Organization
Chromatin Remodeling
Protein Domain Specific Binding
Nucleus
Telomere Maintenance
Nucleoplasm
Energy Reserve Metabolic Process
Chromosome Organization
Glycogen Metabolic Process
Alcohol Dehydrogenase (NADP+) Activity
Cellular Detoxification Of Aldehyde
Extracellular Exosome
Telomere Maintenance In Response To DNA Damage
Myelin Maintenance
Negative Regulation Of T-circle Formation
Polysaccharide Metabolic Process
Nucleic Acid Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Maintenance Of Protein Localization In Organelle
DNA Metabolic Process
Plasma Membrane Organization
Quinolinate Biosynthetic Process
Allyl-alcohol Dehydrogenase Activity
DNA Recombination
Helicase Activity
Regulation Of Growth
Generation Of Precursor Metabolites And Energy
Calcium-dependent Phospholipid Binding
Negative Regulation Of DNA Metabolic Process
Cadherin Binding
Regulation Of Cellular Response To Stress
Quinolinate Metabolic Process
Mre11 Complex
Negative Regulation Of Cellular Component Organization
Carbohydrate Metabolic Process
Regulation Of Cell Growth
Actin Monomer Binding
Positive Regulation Of Proteolysis
Maintenance Of Protein Location In Cell
RNA-templated DNA Biosynthetic Process
Shelterin Complex
Nuclear Telomere Cap Complex
G-rich Strand Telomeric DNA Binding
Telomere Capping
Telomeric DNA Binding
RNA-templated DNA Biosynthetic Process
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of DNA Recombination At Telomere
Nucleic Acid Metabolic Process
Negative Regulation Of Telomere Maintenance
Nucleobase-containing Compound Metabolic Process
Chromosome
Positive Regulation Of Telomere Maintenance
Telomerase Activity
Protection From Non-homologous End Joining At Telomere
Negative Regulation Of Chromosome Organization
DNA Biosynthetic Process
Telomeric D-loop Disassembly
Double-stranded Telomeric DNA Binding
Nucleobase-containing Compound Biosynthetic Process
Telomere Maintenance
Nuclear Body
Telomeric Loop Disassembly
Positive Regulation Of Chromosome Organization
Protein Localization To Chromosome, Telomeric Region
Regulation Of Telomere Maintenance
Telomere Maintenance In Response To DNA Damage
Telomere Organization
Negative Regulation Of DNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Nucleoplasm
Telomere Maintenance Via Telomerase
Chromosome, Telomeric Region
Retinoic Acid Receptor Signaling Pathway
MRNA Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Viral Genome Replication
Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Chromosome Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Telomere Maintenance Via Telomerase
Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
Spliceosomal Complex Assembly
Regulation Of Primary Metabolic Process
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Tagcloud (Intersection)
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