TERF2IP and NOL3

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TERF2IP	NOL3
Description		TERF2 interacting protein	nucleolar protein 3
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Sarcoplasm Sarcoplasmic Reticulum
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	RNA Binding Signaling Receptor Binding Death Receptor Binding Calcium Ion Binding Protein Binding Death Effector Domain Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Caspase Binding
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Response To Hypoxia Blood Vessel Remodeling Response To Ischemia MRNA Splice Site Recognition MRNA Processing Apoptotic Process RNA Splicing Negative Regulation Of Signal Transduction Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Muscle Atrophy Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Injury Involved In Regulation Of Muscle Adaptation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Complex Oligomerization Negative Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Weight ( 34074324)
Interacting Genes		122 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414	17 interacting genes: BAX CASP2 CASP8 CSNK2A1 ETNK2 FADD NIF3L1 POT1 SIRPA SRSF9 TERF1 TERF2IP TFPT TINF2 TRAF6 UBQLN2 VASP
Entrez ID		54386	8996
HPRD ID		05452	05572
Ensembl ID		ENSG00000166848	ENSG00000140939
Uniprot IDs		Q9NYB0	O60936 Q5TZN6
PDB IDs		1FEX 3K6G 4RQI 7OZ0 8RD4	4UZ0
Enriched GO Terms of Interacting Partners?		Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Execution Phase Of Apoptosis Positive Regulation Of Telomere Maintenance Telomeric DNA Binding Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Tumor Necrosis Factor Receptor Binding Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Death Effector Domain Binding Telomere Assembly Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Organization Regulation Of Cellular Response To Stress Ripoptosome CD95 Death-inducing Signaling Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Death-inducing Signaling Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Chromosome, Telomeric Region Positive Regulation Of Myeloid Leukocyte Differentiation TRAIL-activated Apoptotic Signaling Pathway Telomeric D-loop Disassembly Identical Protein Binding
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