CTBP1 and MAML2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		CTBP1	MAML2
Description		C-terminal binding protein 1	mastermind like transcriptional coactivator 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Notch Signaling Pathway Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Endocytosis White Fat Cell Differentiation Regulation Of Cell Cycle Synaptic Vesicle Clustering	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 23322567) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 23456168) Hematocrit ( 32888494) Hemoglobin ( 32888494) Influenza A (H1N1) severity ( 26379185) Keratoconus ( 31855235) Methadone dose in opioid dependence ( 28115739) Non-glioblastoma glioma ( 28346443) Pelvic organ prolapse ( 26545240) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Response to treatment for acute lymphoblastic leukemia ( 19176441) Ulcerative colitis ( 23128233 28067908) Waist-to-hip circumference ratio (alcohol intake interaction) ( 23192594)
Interacting Genes		101 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CCDC9 CDC23 CDKN2D CEP68 CHD3 CPSF7 CREBBP CRY2 CTBP2 CTNNA1 DCAF6 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FUNDC1 GNL3L GTF2B H2AX H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KLF12 LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PKP2 PLCB1 PNN PRKAA1 PRKCI PRPF19 PRPF6 PRRC2B RAI2 RB1 RBBP5 RBBP8 RBM14 RBM22 RIPK4 RNF111 SART3 SF1 SIN3A SNRPN SNW1 SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 TSHZ3 UNKL ZBP1 ZEB1 ZEB2 ZFPM2 ZNF219 ZNF750	8 interacting genes: CREBBP CTBP1 DIABLO NEDD4 NOTCH1 NOTCH2 NOTCH3 NOTCH4
Entrez ID		1487	84441
HPRD ID		04015	09608
Ensembl ID		ENSG00000159692	ENSG00000184384
Uniprot IDs		H0Y8U5 Q13363 X5D8Y5	Q8IZL2
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR 6V89 6V8A 7KWM 8ARI
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone Deacetylase Complex Chromatin Remodeling Nuclear Speck RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Organization Negative Regulation Of Metabolic Process Protein Lysine Deacetylase Activity Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Response To Stress Histone Deacetylase Activity Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Histone Deacetylase Binding Nucleic Acid Metabolic Process Transcription Coactivator Activity	Notch Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Coactivator Activity Negative Regulation Of RNA Biosynthetic Process Tube Morphogenesis Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Cell Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Luteolysis Atrioventricular Node Development Glomerular Capillary Formation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription Of Notch Receptor Target Signaling Receptor Activity Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Adhesion Molecule Production Anatomical Structure Morphogenesis Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Macromolecule Metabolic Process Blood Vessel Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Endocardial Cushion Development Left/right Axis Specification Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of RNA Metabolic Process Morphogenesis Of An Epithelial Sheet Neuron Projection Development Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nephron Tubule Development Regulation Of RNA Biosynthetic Process Notch Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Renal Tubule Development Receptor Complex
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