PLEK and RHOU

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		PLEK	RHOU
Description		pleckstrin	ras homolog family member U
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatase Activator Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Platelet Degranulation Vesicle Docking Involved In Exocytosis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Inositol Phosphate Biosynthetic Process Cell Projection Organization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Depolymerization Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Cortical Actin Cytoskeleton Organization Ruffle Organization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Integrin Activation Intracellular Signal Transduction Inositol Phosphate Metabolic Process Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Diameter Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Platelet Aggregation Protein Secretion By Platelet	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Platelet degranulation	Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Anger ( 24489884) Basophil count ( 32888494) Celiac disease ( 20190752) Lymphocyte count ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 19043545) Monocyte count ( 32888494) Multiple sclerosis ( 24076602 31604244 21833088 22190364) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Venous thromboembolism ( 31420334) White blood cell count ( 32888494)	Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		4 interacting genes: ACVR1 INPP5A RHOU TGFBR1	126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		5341	58480
HPRD ID		15935	06965
Ensembl ID		ENSG00000115956	ENSG00000116574
Uniprot IDs		P08567	Q7L0Q8
PDB IDs		1PLS 1W4M 1X05 1XX0 1ZM0 2CSO 2I5C 2I5F	2Q3H
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Pharyngeal System Development Transforming Growth Factor Beta Binding Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Regulation Of Intracellular Signal Transduction Endocardial Cushion Cell Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Ameboidal-type Cell Migration Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Receptor Complex Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Heart Development Tube Morphogenesis Atrial Septum Primum Morphogenesis Cell Adhesion Involved In Heart Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Cell Communication Negative Regulation Of Apoptotic Signaling Pathway Endocardial Cushion Fusion BMP Receptor Activity Cardiac Muscle Cell Fate Commitment	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin
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