PLEK and INPP5A

Number of citations: 0 (PubMedID 8999861)
Data Source: HPRD (in vitro)

		PLEK	INPP5A
Name		pleckstrin	inositol polyphosphate-5-phosphatase A
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane	Plasma Membrane Membrane Dendrite Cell Projection
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatase Activator Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding	Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity PH Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Platelet Degranulation Vesicle Docking Involved In Exocytosis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Inositol Phosphate Biosynthetic Process Cell Projection Organization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Depolymerization Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Cortical Actin Cytoskeleton Organization Ruffle Organization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Integrin Activation Intracellular Signal Transduction Inositol Phosphate Metabolic Process Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Diameter Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Platelet Aggregation Protein Secretion By Platelet	Phosphate-containing Compound Metabolic Process Organophosphate Metabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Platelet degranulation	Synthesis of IP2, IP, and Ins in the cytosol
GWAS		Anger ( 24489884 ) Basophil count ( 32888494 ) Celiac disease ( 20190752 ) Lymphocyte count ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 19043545 ) Monocyte count ( 32888494 ) Multiple sclerosis ( 24076602 31604244 21833088 22190364 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Venous thromboembolism ( 31420334 ) White blood cell count ( 32888494 )	Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gait speed in old age ( 28077804 ) Heel bone mineral density ( 28869591 30598549 ) Migraine ( 27182965 ) Primary sclerosing cholangitis ( 27992413 ) Pulse pressure ( 30578418 ) Systolic blood pressure ( 30224653 30578418 ) Triglyceride levels ( 32203549 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 30275531 )
Novel Interactors		None recorded	1 novel interactors: TUBGCP2
Interacting Genes		4 interacting genes: ACVR1 INPP5A RHOU TGFBR1	3 interacting genes: PLEK TEAD2 YWHAZ
Entrez ID		5341	3632
HPRD ID		15935	02521
Ensembl ID		ENSG00000115956	ENSG00000068383
Uniprot IDs		P08567	Q14642
PDB IDs		1PLS 1W4M 1X05 1XX0 1ZM0 2CSO 2I5C 2I5F	Not available
GO Terms Enriched among Interactors		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Pharyngeal System Development Transforming Growth Factor Beta Binding Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Regulation Of Intracellular Signal Transduction Endocardial Cushion Cell Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Ameboidal-type Cell Migration Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Receptor Complex Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Heart Development Tube Morphogenesis Atrial Septum Primum Morphogenesis Cell Adhesion Involved In Heart Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Cell Communication Negative Regulation Of Apoptotic Signaling Pathway Endocardial Cushion Fusion BMP Receptor Activity Cardiac Muscle Cell Fate Commitment	Regulation Of Cell Diameter Protein Secretion By Platelet Negative Regulation Of Inositol Phosphate Biosynthetic Process Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Synaptic Target Recognition Tube Formation Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Platelet Degranulation Golgi Reassembly TEAD-YAP Complex Lateral Mesoderm Development Phosphatase Activator Activity Phosphoserine Residue Binding Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Platelet Activation Regulation Of Lysosome Organization Golgi Localization Establishment Of Golgi Localization Animal Organ Development Notochord Development Paraxial Mesoderm Development Microtubule Minus-end Binding Gamma-tubulin Complex Organelle Localization Positive Regulation Of Protein Depolymerization Intracellular Signal Transduction Regulation Of Integrin Activation Antibacterial Innate Immune Response