PLEK

Name	pleckstrin
Structure
Interactors	4 interactors: ACVR1 INPP5A RHOU TGFBR1
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatase Activator Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Platelet Degranulation Vesicle Docking Involved In Exocytosis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Inositol Phosphate Biosynthetic Process Cell Projection Organization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Depolymerization Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Cortical Actin Cytoskeleton Organization Ruffle Organization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Integrin Activation Intracellular Signal Transduction Inositol Phosphate Metabolic Process Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Diameter Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Platelet Aggregation Protein Secretion By Platelet
Pathways	Platelet degranulation
GWAS	Anger ( 24489884 ) Basophil count ( 32888494 ) Celiac disease ( 20190752 ) Lymphocyte count ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 19043545 ) Monocyte count ( 32888494 ) Multiple sclerosis ( 24076602 31604244 21833088 22190364 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Venous thromboembolism ( 31420334 ) White blood cell count ( 32888494 )
Entrez ID	5341
HPRD ID	15935
Ensembl ID	ENSG00000115956
Uniprot IDs	P08567
PDB IDs	1PLS 1W4M 1X05 1XX0 1ZM0 2CSO 2I5C 2I5F
GO Terms Enriched among Interactors ?	Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Pharyngeal System Development Transforming Growth Factor Beta Binding Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Regulation Of Intracellular Signal Transduction Endocardial Cushion Cell Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Ameboidal-type Cell Migration Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Receptor Complex Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Heart Development Tube Morphogenesis Atrial Septum Primum Morphogenesis Cell Adhesion Involved In Heart Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Cell Communication Negative Regulation Of Apoptotic Signaling Pathway Endocardial Cushion Fusion BMP Receptor Activity Cardiac Muscle Cell Fate Commitment