PLEK and ACVR1

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		PLEK	ACVR1
Gene Name		pleckstrin	activin A receptor, type I
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Membrane Ruffle Membrane	Integral Component Of Plasma Membrane Apical Part Of Cell Activin Receptor Complex
	Molecular Function	Protein Kinase C Binding Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Platelet Degranulation Vesicle Docking Involved In Exocytosis Integrin-mediated Signaling Pathway Blood Coagulation Positive Regulation Of Platelet Activation Negative Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Inositol-polyphosphate 5-phosphatase Activity Cell Projection Organization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Phospholipase C-inhibiting G-protein Coupled Receptor Signaling Pathway Cortical Actin Cytoskeleton Organization Ruffle Organization Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Integrin Activation Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Phosphatidylinositol Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Diameter Thrombin Receptor Signaling Pathway Platelet Aggregation Protein Kinase C Signaling Protein Secretion By Platelet	G1/S Transition Of Mitotic Cell Cycle Patterning Of Blood Vessels Urogenital System Development In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Mitral Valve Morphogenesis Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Tissue Development Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs			Adenosine triphosphate 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS		Celiac disease ( 20190752) Metabolite levels ( 19043545) Multiple sclerosis ( 22190364 21833088)
Protein-Protein Interactions		3 interactors: ACVR1 INPP5A TGFBR1	64 interactors: AP2B1 BAMBI BMP2 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FCHO1 FGD6 FKBP4 FNTA GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61
Entrez ID		5341	90
HPRD ID		15935	00021
Ensembl ID		ENSG00000115956	ENSG00000115170
Uniprot IDs		P08567	D3DPA4 Q04771
PDB IDs		1PLS 1W4M 1X05 1XX0 1ZM0 2CSO 2I5C 2I5F	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
Enriched GO Terms of Interacting Partners?		Pathway-restricted SMAD Protein Phosphorylation Pharyngeal System Development Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchymal Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Endocardial Cushion Cell Fate Commitment Ameboidal-type Cell Migration Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Heart Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Signal Transduction By Phosphorylation Cell Fate Commitment Stem Cell Differentiation Embryonic Organ Morphogenesis Angiogenesis Mitral Valve Morphogenesis Cardiac Muscle Cell Fate Commitment Urogenital System Development Mitral Valve Development Blood Vessel Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Parathyroid Gland Development Negative Regulation Of Activin Receptor Signaling Pathway Pattern Specification Process Atrial Septum Primum Morphogenesis Endocardial Cell Differentiation Embryonic Organ Development Septum Primum Development In Utero Embryonic Development Blood Vessel Development Heart Development Endothelial Cell Activation Vasculature Development Cellular Response To Growth Factor Stimulus Positive Regulation Of SMAD Protein Import Into Nucleus Phosphate-containing Compound Metabolic Process Response To Growth Factor Regulation Of SMAD Protein Import Into Nucleus Embryonic Morphogenesis	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Intracellular Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Metabolic Process Response To Stimulus BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cell Differentiation Regulation Of Cellular Process Ras Protein Signal Transduction Anatomical Structure Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Skeletal System Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Response To Organic Substance Positive Regulation Of Gene Expression Epithelium Development Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation
Tagcloud ?		anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Difference) ?		anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Intersection) ?