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PLA2G2A and UCHL5
Number of citations of the paper that reports this interaction (PMID
22118674
)
23
Data Source:
BioGRID
(enzymatic study)
PLA2G2A
UCHL5
Gene Name
phospholipase A2, group IIA (platelets, synovial fluid)
ubiquitin carboxyl-terminal hydrolase L5
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Secretory Granule
Extracellular Vesicular Exosome
Proteasome Complex
Nucleus
Cytosol
Ino80 Complex
Molecular Function
Phospholipase A2 Activity
Calcium Ion Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Omega Peptidase Activity
Poly(A) RNA Binding
Proteasome Binding
Biological Process
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Catabolic Process
Low-density Lipoprotein Particle Remodeling
Somatic Stem Cell Maintenance
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Small Molecule Metabolic Process
Phosphatidic Acid Metabolic Process
Glycerophospholipid Biosynthetic Process
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
DNA Repair
DNA Recombination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Lateral Ventricle Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Forebrain Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Pathways
Acyl chain remodelling of PG
Acyl chain remodelling of PE
Synthesis of PA
Metabolism of lipids and lipoproteins
Acyl chain remodelling of PI
Phospholipid metabolism
Glycerophospholipid biosynthesis
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Indomethacin
Diclofenac
Ginkgo biloba
1,4-Butanediol
1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
N-Tridecanoic Acid
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid
6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid
Elaidoylamide
1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide
(S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid
Suramin
Diseases
GWAS
Cannabis dependence (
21668797
)
Protein-Protein Interactions
24 interactors:
ALOX12
BAG6
CEP70
CRMP1
DCN
JOSD2
PLA2G1B
PLA2R1
SENP6
SENP8
UCHL1
UCHL3
UCHL5
USP15
USP2
USP20
USP28
USP4
USP47
USP5
USP7
USP8
VCAN
VIM
96 interactors:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
HAUS7
HBA1
HBA2
HBB
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBE3A
USP28
YWHAZ
ZBED1
Entrez ID
5320
51377
HPRD ID
01397
10293
Ensembl ID
ENSG00000188257
ENSG00000116750
Uniprot IDs
P14555
Q9Y5K5
PDB IDs
1AYP
1BBC
1DB4
1DB5
1DCY
1J1A
1KQU
1KVO
1N28
1N29
1POD
1POE
2GNY
3U8B
3U8D
3U8H
3U8I
3A7S
3IHR
3RII
3RIS
3TB3
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Removal
Protein Deubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Catabolic Process
Proteolysis
Regulation Of Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein K48-linked Deubiquitination
Cellular Metabolic Process
Monoubiquitinated Protein Deubiquitination
Dermatan Sulfate Biosynthetic Process
Regulation Of Phospholipase A2 Activity
Dermatan Sulfate Proteoglycan Biosynthetic Process
Dermatan Sulfate Proteoglycan Metabolic Process
Chondroitin Sulfate Catabolic Process
Protein K63-linked Deubiquitination
Histone Deubiquitination
Chondroitin Sulfate Biosynthetic Process
Metabolic Process
Chondroitin Sulfate Proteoglycan Biosynthetic Process
Regulation Of Protein Stability
Regulation Of Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Leukotriene Metabolic Process
Cellular Process
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Cellular Protein Metabolic Process
Icosanoid Biosynthetic Process
Negative Regulation Of Arachidonic Acid Secretion
Lipoxin B4 Biosynthetic Process
Leukotriene A4 Metabolic Process
Cellular Response To DNA Damage Stimulus
Unsaturated Fatty Acid Biosynthetic Process
Proteoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Chondroitin Sulfate Metabolic Process
Negative Regulation Of Protein Metabolic Process
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
Regulation Of Megakaryocyte Differentiation
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
CENP-A Containing Nucleosome Assembly
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Demethylation
Centromere Complex Assembly
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Gene Silencing
DNA Methylation
Nucleosome Organization
Nucleosome Assembly
Chromatin Assembly
Telomere Maintenance
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Protein Complex Assembly
Regulation Of Gene Expression, Epigenetic
DNA Packaging
Cellular Component Assembly
Regulation Of Myeloid Cell Differentiation
DNA Conformation Change
Chromatin Remodeling
Negative Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Cellular Macromolecular Complex Assembly
Negative Regulation Of Cell Differentiation
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Immune System Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Modification
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Cellular Protein Metabolic Process
Homeostatic Process
Tagcloud
?
1p35
adenomas
adenomatous
alleles
borderline
characterised
colonic
disequilibrium
duodenal
fap
genuine
inherited
locus
modifier
modify
mom1
noncoding
p36
phospholipase
pla2s
polymorphic
polyposis
polyps
secretory
silent
sporadic
syntenic
undetected
Tagcloud (Difference)
?
1p35
adenomas
adenomatous
alleles
borderline
characterised
colonic
disequilibrium
duodenal
fap
genuine
inherited
locus
modifier
modify
mom1
noncoding
p36
phospholipase
pla2s
polymorphic
polyposis
polyps
secretory
silent
sporadic
syntenic
undetected
Tagcloud (Intersection)
?