PLA2G2A and USP8

Number of citations of the paper that reports this interaction (PMID 22118674)
23

Data Source:
BioGRID (enzymatic study)

		PLA2G2A	USP8
Gene Name		phospholipase A2, group IIA (platelets, synovial fluid)	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Secretory Granule Extracellular Vesicular Exosome	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Low-density Lipoprotein Particle Remodeling Somatic Stem Cell Maintenance Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Small Molecule Metabolic Process Phosphatidic Acid Metabolic Process Glycerophospholipid Biosynthetic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS	Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs		Indomethacin Diclofenac Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid Elaidoylamide 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid Suramin
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ALOX12 BAG6 CEP70 CRMP1 DCN JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		5320	9101
HPRD ID		01397	04405
Ensembl ID		ENSG00000188257	ENSG00000138592
Uniprot IDs		P14555	P40818
PDB IDs		1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Proteolysis Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K48-linked Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Dermatan Sulfate Biosynthetic Process Regulation Of Phospholipase A2 Activity Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Chondroitin Sulfate Biosynthetic Process Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Regulation Of Protein Stability Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukotriene Metabolic Process Cellular Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Icosanoid Biosynthetic Process Negative Regulation Of Arachidonic Acid Secretion Lipoxin B4 Biosynthetic Process Leukotriene A4 Metabolic Process Cellular Response To DNA Damage Stimulus Unsaturated Fatty Acid Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Negative Regulation Of Protein Metabolic Process	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?