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PLA2G2A and USP15
Number of citations of the paper that reports this interaction (PubMedID
22118674
)
0
Data Source:
BioGRID
(enzymatic study)
PLA2G2A
USP15
Description
phospholipase A2 group IIA
ubiquitin specific peptidase 15
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Secretory Granule
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nuclear Body
Molecular Function
Catalytic Activity
Phospholipase A2 Activity
Calcium Ion Binding
Phospholipid Binding
Hydrolase Activity
Metal Ion Binding
Calcium-dependent Phospholipase A2 Activity
Catalytic Activity
Cysteine-type Endopeptidase Activity
Cysteine-type Deubiquitinase Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Identical Protein Binding
SMAD Binding
Ubiquitin-modified Histone Reader Activity
Deubiquitinase Activity
K48-linked Deubiquitinase Activity
Biological Process
Lipid Metabolic Process
Phospholipid Metabolic Process
Inflammatory Response
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Catabolic Process
Killing Of Cells Of Another Organism
Low-density Lipoprotein Particle Remodeling
Intestinal Stem Cell Homeostasis
Angiotensin-activated Signaling Pathway
Negative Regulation Of T Cell Proliferation
Defense Response To Bacterium
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidylglycerol Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonate Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Neutrophil Activation
Proteolysis
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Deubiquitination
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Monoubiquitinated Protein Deubiquitination
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of RNA Metabolic Process
Transcription Elongation-coupled Chromatin Remodeling
Positive Regulation Of RIG-I Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Negative Regulation Of Antifungal Innate Immune Response
Protein K27-linked Deubiquitination
Pathways
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Antimicrobial peptides
Downregulation of TGF-beta receptor signaling
UCH proteinases
Ub-specific processing proteases
Drugs
Indomethacin
Ginkgo biloba
1,4-Butanediol
1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
N-Tridecanoic Acid
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
Lauric acid
(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid
6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid
Elaidamide
(2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate
KH064
Suramin
Varespladib methyl
Diseases
GWAS
Blood protein levels (
30072576
)
Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP (
31070471
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Alopecia areata (
25608926
)
Metabolite levels (
23823483
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Pulmonary function decline (
22424883
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Interacting Genes
26 interacting genes:
ALOX12
BAG6
CEP70
CRMP1
DCN
ITGAV
ITGB3
JOSD2
PLA2G1B
PLA2R1
SENP6
SENP8
UCHL1
UCHL3
UCHL5
USP15
USP2
USP20
USP28
USP4
USP47
USP5
USP7
USP8
VCAN
VIM
61 interacting genes:
BAP1
BMI1
BMPR1A
BRAP
CARD9
CCDC57
CDC73
CSNK1A1
FHL1
GEMIN4
GLUL
GOLGA2
GOLGA6A
GSPT1
H2BC21
IL1R2
JOSD1
KEAP1
MAD1L1
MDC1
MDM2
OTUB1
PARP1
PHF7
PIBF1
PLA2G2A
PRPF31
RBCK1
RIGI
RNF126
RNF144B
RNF26
SENP3
SENP8
SMURF2
SPDL1
STAM
STK33
SYVN1
TEX11
TRAF6
TRIM17
TRIM21
TRIM25
TRIM46
TRIM5
TRIM54
TRIM63
TRIM74
UBC
UCHL1
UCHL3
USP14
USP2
USP20
USP21
USP28
USP33
USP51
USP8
YOD1
Entrez ID
5320
9958
HPRD ID
01397
05293
Ensembl ID
ENSG00000188257
ENSG00000135655
Uniprot IDs
P14555
Q9Y4E8
PDB IDs
1AYP
1BBC
1DB4
1DB5
1DCY
1J1A
1KQU
1KVO
1N28
1N29
1POD
1POE
3U8B
3U8D
3U8H
3U8I
5G3N
1W6V
3LMN
3PPA
3PV1
3T9L
4A3O
4A3P
5JJW
6CPM
6CRN
6DJ9
6GH9
6GHA
6ML1
7R2G
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Removal
Protein Deubiquitination
Cysteine-type Deubiquitinase Activity
Cysteine-type Peptidase Activity
Peptidase Activity
Deubiquitinase Activity
Post-translational Protein Modification
Hydrolase Activity
Proteolysis
Cysteine-type Endopeptidase Activity
Protein Modification Process
Regulation Of Protein Stability
Protein Metabolic Process
Monoubiquitinated Protein Deubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Catabolic Process
Integrin Alphav-beta3 Complex
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Podocyte Apoptotic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
K48-linked Deubiquitinase Activity
Cytosol
Alphav-beta3 Integrin-PKCalpha Complex
Alphav-beta3 Integrin-HMGB1 Complex
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Biological Quality
Protein K48-linked Deubiquitination
Extracellular Matrix Binding
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Regulation Of Intracellular Signal Transduction
Apolipoprotein A-I-mediated Signaling Pathway
C-X3-C Chemokine Binding
Negative Regulation Of Lipoprotein Metabolic Process
Neuregulin Binding
Negative Regulation Of Lipid Transport
DeNEDDylase Activity
Macromolecule Metabolic Process
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteolysis
Positive Regulation Of Signal Transduction
Negative Regulation Of Low-density Lipoprotein Particle Clearance
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Insulin-like Growth Factor I Binding
Positive Regulation Of Osteoblast Proliferation
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Catabolic Process
Post-translational Protein Modification
Protein Modification Process
Cysteine-type Deubiquitinase Activity
Protein Modification By Small Protein Removal
Protein Deubiquitination
Proteolysis
Cysteine-type Peptidase Activity
Protein Metabolic Process
Macromolecule Metabolic Process
Ubiquitin Protein Ligase Activity
Proteolysis Involved In Protein Catabolic Process
Protein Ubiquitination
Peptidase Activity
Protein K48-linked Deubiquitination
Modification-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Ubiquitin-protein Transferase Activity
DeNEDDylase Activity
Catabolic Process
Zinc Ion Binding
Cytosol
Protein Polyubiquitination
Proteasomal Protein Catabolic Process
Cytoplasm
Deubiquitinase Activity
Protein Catabolic Process
Innate Immune Response
Ubiquitin Binding
Cysteine-type Endopeptidase Activity
Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Immune System Process
Transferase Activity
Defense Response To Symbiont
Metal Ion Binding
Defense Response To Other Organism
Response To External Biotic Stimulus
Response To Stress
Response To Other Organism
Hydrolase Activity
Protein K63-linked Deubiquitination
Protein K48-linked Ubiquitination
Regulation Of Signal Transduction
Antiviral Innate Immune Response
Regulation Of Mitotic Cell Cycle
Regulation Of Double-strand Break Repair Via Homologous Recombination
Ubiquitin Protein Ligase Binding
Regulation Of Double-strand Break Repair
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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