PLA2G2A and ITGB3

Number of citations of the paper that reports this interaction (PubMedID 18635536)
53

Data Source:
BioGRID (pull down)

		PLA2G2A	ITGB3
Description		phospholipase A2 group IIA	integrin subunit beta 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Secretory Granule Perinuclear Region Of Cytoplasm Extracellular Exosome	Ruffle Nucleus Nucleoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Filopodium Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Protein-containing Complex Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Melanosome Cell Projection Receptor Complex Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Alpha9-beta1 Integrin-ADAM8 Complex Synaptic Membrane Glycinergic Synapse Glutamatergic Synapse
	Molecular Function	Catalytic Activity Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity	Virus Receptor Activity Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Protein Kinase C Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding Enzyme Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Neuregulin Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inflammatory Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Killing Of Cells Of Another Organism Low-density Lipoprotein Particle Remodeling Intestinal Stem Cell Homeostasis Angiotensin-activated Signaling Pathway Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Neutrophil Activation	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Leukocyte Migration Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Blood Coagulation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Negative Regulation Of Lipid Storage Negative Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Smooth Muscle Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Negative Regulation Of Lipid Transport Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Wound Healing, Spreading Of Epidermal Cells Response To Platelet-derived Growth Factor Cellular Response To Platelet-derived Growth Factor Stimulus Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Apoptotic Cell Clearance Regulation Of Bone Resorption Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Developmental Process Negative Chemotaxis Regulation Of Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Serotonin Uptake Angiogenesis Involved In Wound Healing Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Glomerular Mesangial Cell Proliferation Blood Coagulation, Fibrin Clot Formation Maintenance Of Postsynaptic Specialization Structure Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Trophoblast Cell Migration Regulation Of Extracellular Matrix Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Antimicrobial peptides	Platelet degranulation Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Indomethacin Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid Lauric acid (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid Elaidamide (2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate KH064 Suramin Varespladib methyl	Abciximab Eptifibatide Antithymocyte immunoglobulin (rabbit) Levothyroxine Tirofiban Resveratrol Lefradafiban LM-609 Fradafiban Ferric maltol
Diseases			Allograft rejection Glanzmann thrombasthenia
GWAS		Blood protein levels ( 30072576) Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Immunoglobulin light chain (AL) amyloidosis ( 28025584)	Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 33713608) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		26 interacting genes: ALOX12 BAG6 CEP70 CRMP1 DCN ITGAV ITGB3 JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM	50 interacting genes: AKT1 ANGPTL3 APP CAPN1 CD36 CDK1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGFR1 FGG FLNA FLNB FN1 GRIA2 HRAS ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR MAPK3 MIIP NID1 NUMB P2RY2 P4HB PDGFRA PDGFRB PDK1 PDPK1 PECAM1 PLA2G2A PLA2G4A PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN
Entrez ID		5320	3690
HPRD ID		01397	01428
Ensembl ID		ENSG00000188257	ENSG00000259207
Uniprot IDs		P14555	P05106
PDB IDs		1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 3U8B 3U8D 3U8H 3U8I 5G3N	1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1S4X 1TYE 1U8C 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2MTP 2N9Y 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4Z7N 4Z7O 4Z7Q 5HDB 6AVQ 6AVR 6AVU 6BXB 6BXF 6BXJ 6CKB 6MK0 6MSL 6MSU 6NAJ 6V4P 7KN0 7L8P 7LA4 7TCT 7TD8 7THO 7TMZ 7TPD 7U60 7U9F 7U9V 7UBR 7UCY 7UDG 7UDH 7UE0 7UFH 7UH8 7UJE 7UJK 7UK9 7UKO 7UKP 7UKT 8GCD 8GCE 8IJ5 8T2U 8T2V 8XEI 8XEK 8XEL 8XEN 8XER 8XEZ 8XF6 8XFG 8XFO 9AXL 9DEQ 9DER
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Peptidase Activity Deubiquitinase Activity Post-translational Protein Modification Hydrolase Activity Proteolysis Cysteine-type Endopeptidase Activity Protein Modification Process Regulation Of Protein Stability Protein Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Integrin Alphav-beta3 Complex Negative Regulation Of Protein Metabolic Process Positive Regulation Of Podocyte Apoptotic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process K48-linked Deubiquitinase Activity Cytosol Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Biological Quality Protein K48-linked Deubiquitination Extracellular Matrix Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Regulation Of Intracellular Signal Transduction Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Negative Regulation Of Lipid Transport DeNEDDylase Activity Macromolecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Positive Regulation Of Signal Transduction Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Ubiquitin-dependent Protein Catabolic Process Extracellular Matrix Structural Constituent Conferring Compression Resistance Insulin-like Growth Factor I Binding Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Catabolic Process	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Focal Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Integrin-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cell Adhesion Integrin Binding Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell-substrate Adhesion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Angiogenesis Cell-matrix Adhesion Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Anchoring Junction Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction External Side Of Plasma Membrane Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Protein Autophosphorylation Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport
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