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PLA2G2A and JOSD2
Number of citations of the paper that reports this interaction (PMID
22118674
)
23
Data Source:
BioGRID
(enzymatic study)
PLA2G2A
JOSD2
Gene Name
phospholipase A2, group IIA (platelets, synovial fluid)
Josephin domain containing 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Secretory Granule
Extracellular Vesicular Exosome
Cytosol
Molecular Function
Phospholipase A2 Activity
Calcium Ion Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Ubiquitin-specific Protease Activity
Omega Peptidase Activity
Biological Process
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Catabolic Process
Low-density Lipoprotein Particle Remodeling
Somatic Stem Cell Maintenance
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Small Molecule Metabolic Process
Phosphatidic Acid Metabolic Process
Glycerophospholipid Biosynthetic Process
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Proteolysis
Protein Deubiquitination
Pathways
Acyl chain remodelling of PG
Acyl chain remodelling of PE
Synthesis of PA
Metabolism of lipids and lipoproteins
Acyl chain remodelling of PI
Phospholipid metabolism
Glycerophospholipid biosynthesis
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Drugs
Indomethacin
Diclofenac
Ginkgo biloba
1,4-Butanediol
1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
N-Tridecanoic Acid
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid
6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid
Elaidoylamide
1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide
(S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid
Suramin
Diseases
GWAS
Protein-Protein Interactions
24 interactors:
ALOX12
BAG6
CEP70
CRMP1
DCN
JOSD2
PLA2G1B
PLA2R1
SENP6
SENP8
UCHL1
UCHL3
UCHL5
USP15
USP2
USP20
USP28
USP4
USP47
USP5
USP7
USP8
VCAN
VIM
3 interactors:
PLA2G2A
STUB1
UBC
Entrez ID
5320
126119
HPRD ID
01397
15297
Ensembl ID
ENSG00000188257
ENSG00000161677
Uniprot IDs
P14555
Q7Z7N5
Q8TAC2
PDB IDs
1AYP
1BBC
1DB4
1DB5
1DCY
1J1A
1KQU
1KVO
1N28
1N29
1POD
1POE
2GNY
3U8B
3U8D
3U8H
3U8I
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Removal
Protein Deubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Catabolic Process
Proteolysis
Regulation Of Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein K48-linked Deubiquitination
Cellular Metabolic Process
Monoubiquitinated Protein Deubiquitination
Dermatan Sulfate Biosynthetic Process
Regulation Of Phospholipase A2 Activity
Dermatan Sulfate Proteoglycan Biosynthetic Process
Dermatan Sulfate Proteoglycan Metabolic Process
Chondroitin Sulfate Catabolic Process
Protein K63-linked Deubiquitination
Histone Deubiquitination
Chondroitin Sulfate Biosynthetic Process
Metabolic Process
Chondroitin Sulfate Proteoglycan Biosynthetic Process
Regulation Of Protein Stability
Regulation Of Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Leukotriene Metabolic Process
Cellular Process
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Cellular Protein Metabolic Process
Icosanoid Biosynthetic Process
Negative Regulation Of Arachidonic Acid Secretion
Lipoxin B4 Biosynthetic Process
Leukotriene A4 Metabolic Process
Cellular Response To DNA Damage Stimulus
Unsaturated Fatty Acid Biosynthetic Process
Proteoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Chondroitin Sulfate Metabolic Process
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Protein Ubiquitination
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Protein Polyubiquitination
Regulation Of Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Protein Ubiquitination
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Positive Regulation Of Protein Catabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Catabolic Process
Positive Regulation Of Proteolysis
Ubiquitin-dependent SMAD Protein Catabolic Process
Regulation Of Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Viral Protein Processing
Modification-dependent Protein Catabolic Process
Low-density Lipoprotein Particle Remodeling
Regulation Of Glucocorticoid Metabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Transferase Activity
Cellular Protein Catabolic Process
Protein Ubiquitination
Misfolded Or Incompletely Synthesized Protein Catabolic Process
Phosphatidylinositol Acyl-chain Remodeling
Cellular Response To Misfolded Protein
Cellular Response To Growth Factor Stimulus
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
DNA Repair
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Response To Misfolded Protein
Protein Catabolic Process
Regulation Of Proteolysis
Phosphatidylethanolamine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Notch Receptor Processing
Virion Assembly
Tagcloud
?
1p35
adenomas
adenomatous
alleles
borderline
characterised
colonic
disequilibrium
duodenal
fap
genuine
inherited
locus
modifier
modify
mom1
noncoding
p36
phospholipase
pla2s
polymorphic
polyposis
polyps
secretory
silent
sporadic
syntenic
undetected
Tagcloud (Difference)
?
1p35
adenomas
adenomatous
alleles
borderline
characterised
colonic
disequilibrium
duodenal
fap
genuine
inherited
locus
modifier
modify
mom1
noncoding
p36
phospholipase
pla2s
polymorphic
polyposis
polyps
secretory
silent
sporadic
syntenic
undetected
Tagcloud (Intersection)
?