PLA2G2A and PLA2R1

Number of citations of the paper that reports this interaction (PubMedID 7721806)
0

Data Source:
HPRD (in vitro)

		PLA2G2A	PLA2R1
Description		phospholipase A2 group IIA	phospholipase A2 receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Secretory Granule Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Catalytic Activity Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity	Phospholipase A2 Inhibitor Activity Carbohydrate Binding Signaling Receptor Activity Phospholipase Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inflammatory Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Killing Of Cells Of Another Organism Low-density Lipoprotein Particle Remodeling Intestinal Stem Cell Homeostasis Angiotensin-activated Signaling Pathway Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Neutrophil Activation	Positive Regulation Of Cytokine Production Endocytosis Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonate Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Arachidonate Secretion Positive Regulation Of Podocyte Apoptotic Process
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Antimicrobial peptides	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		Indomethacin Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid Lauric acid (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid Elaidamide (2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate KH064 Suramin Varespladib methyl
Diseases
GWAS		Blood protein levels ( 30072576) Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Immunoglobulin light chain (AL) amyloidosis ( 28025584)	Bilirubin levels ( 20639394) Blood protein levels ( 30072576) Crohn's disease ( 26192919) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 26192919) Membranous nephropathy ( 27333618 32231244) Platelet count ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278) Tourette syndrome ( 30818990) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: ALOX12 BAG6 CEP70 CRMP1 DCN ITGAV ITGB3 JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM	2 interacting genes: PLA2G10 PLA2G2A
Entrez ID		5320	22925
HPRD ID		01397	09222
Ensembl ID		ENSG00000188257	ENSG00000153246
Uniprot IDs		P14555	B7ZML4 Q13018
PDB IDs		1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 3U8B 3U8D 3U8H 3U8I 5G3N	6JLI 7QSR
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Peptidase Activity Deubiquitinase Activity Post-translational Protein Modification Hydrolase Activity Proteolysis Cysteine-type Endopeptidase Activity Protein Modification Process Regulation Of Protein Stability Protein Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Integrin Alphav-beta3 Complex Negative Regulation Of Protein Metabolic Process Positive Regulation Of Podocyte Apoptotic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process K48-linked Deubiquitinase Activity Cytosol Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Biological Quality Protein K48-linked Deubiquitination Extracellular Matrix Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Regulation Of Intracellular Signal Transduction Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Negative Regulation Of Lipid Transport DeNEDDylase Activity Macromolecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Positive Regulation Of Signal Transduction Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Ubiquitin-dependent Protein Catabolic Process Extracellular Matrix Structural Constituent Conferring Compression Resistance Insulin-like Growth Factor I Binding Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Catabolic Process	Intestinal Stem Cell Homeostasis Positive Regulation Of Macrophage Derived Foam Cell Differentiation Low-density Lipoprotein Particle Remodeling Calcium-dependent Phospholipase A2 Activity Arachidonate Secretion Phospholipase A2 Activity Phosphatidylglycerol Metabolic Process Phosphatidylethanolamine Metabolic Process Phosphatidic Acid Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Long-chain Fatty Acid Transport Phosphatidylcholine Metabolic Process Fatty Acid Transport Phospholipid Binding Monocarboxylic Acid Transport Homeostasis Of Number Of Cells Platelet Activating Factor Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Lysophospholipid Transport Carboxylic Acid Transport Organic Acid Transport Glycerophospholipid Metabolic Process Lipid Catabolic Process Positive Regulation Of Arachidonate Secretion Lipid Transport Glycerolipid Metabolic Process Regulation Of Arachidonate Secretion Phospholipid Metabolic Process Organic Anion Transport 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Platelet Activating Factor Metabolic Process Positive Regulation Of Acrosome Reaction Regulation Of Inflammatory Response Regulation Of Neutrophil Activation Voltage-gated Sodium Channel Complex Phosphatidylcholine Catabolic Process Positive Regulation Of Prostaglandin Secretion Production Of Molecular Mediator Involved In Inflammatory Response Multicellular Organismal-level Homeostasis Regulation Of Acrosome Reaction Negative Regulation Of Cholesterol Efflux Secretion Prostaglandin Biosynthetic Process Voltage-gated Sodium Channel Activity Positive Regulation Of Icosanoid Secretion Angiotensin-activated Signaling Pathway Calcium Ion Binding Node Of Ranvier
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