PLA2G2A and PLA2R1

Number of citations of the paper that reports this interaction (PMID 7721806)
18

Data Source:
HPRD (in vitro)

		PLA2G2A	PLA2R1
Gene Name		phospholipase A2, group IIA (platelets, synovial fluid)	phospholipase A2 receptor 1, 180kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Secretory Granule Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity	Receptor Activity Carbohydrate Binding Phospholipase Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Low-density Lipoprotein Particle Remodeling Somatic Stem Cell Maintenance Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Small Molecule Metabolic Process Phosphatidic Acid Metabolic Process Glycerophospholipid Biosynthetic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium	Cytokine Production Endocytosis Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonic Acid Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Arachidonic Acid Secretion
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs		Indomethacin Diclofenac Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid Elaidoylamide 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid Suramin
Diseases
GWAS			Bilirubin levels ( 20639394) Nephropathy (idiopathic membranous) ( 21323541)
Protein-Protein Interactions		24 interactors: ALOX12 BAG6 CEP70 CRMP1 DCN JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM	2 interactors: PLA2G10 PLA2G2A
Entrez ID		5320	22925
HPRD ID		01397	09222
Ensembl ID		ENSG00000188257	ENSG00000153246
Uniprot IDs		P14555	B7ZML4 Q13018
PDB IDs		1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Proteolysis Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K48-linked Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Dermatan Sulfate Biosynthetic Process Regulation Of Phospholipase A2 Activity Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Chondroitin Sulfate Biosynthetic Process Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Regulation Of Protein Stability Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukotriene Metabolic Process Cellular Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Icosanoid Biosynthetic Process Negative Regulation Of Arachidonic Acid Secretion Lipoxin B4 Biosynthetic Process Leukotriene A4 Metabolic Process Cellular Response To DNA Damage Stimulus Unsaturated Fatty Acid Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Negative Regulation Of Protein Metabolic Process	Phosphatidylinositol Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Phosphatidylserine Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Macrophage Derived Foam Cell Differentiation Phosphatidylcholine Metabolic Process Cellular Biogenic Amine Metabolic Process Amine Metabolic Process Glycerophospholipid Biosynthetic Process Lysophospholipid Transport Phosphatidylinositol Metabolic Process Phospholipid Biosynthetic Process Lipid Catabolic Process Cellular Modified Amino Acid Metabolic Process Glycerophospholipid Metabolic Process Alcohol Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Negative Regulation Of Cholesterol Efflux Positive Regulation Of Arachidonic Acid Secretion Lipid Biosynthetic Process Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Transport Low-density Lipoprotein Particle Remodeling Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Cell Differentiation Positive Regulation Of Icosanoid Secretion Cellular Lipid Metabolic Process Organophosphate Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Transport Regulation Of Macrophage Activation Plasma Lipoprotein Particle Remodeling Regulation Of Fatty Acid Transport Positive Regulation Of Lipid Storage Lipid Metabolic Process Regulation Of Cholesterol Transport Carbohydrate Derivative Transport Regulation Of Cell Differentiation Regulation Of Lipid Storage Positive Regulation Of Lipid Transport Regulation Of Plasma Lipoprotein Particle Levels Arachidonic Acid Metabolic Process Defense Response To Gram-positive Bacterium
Tagcloud ?		1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected	2000s alloimmune ancestry basel cationic come definition deposited dqa1 endopeptidase exaggerated faithful heymann idiopathic inspired karger membranous mn nephritis nephropathy opening pathomechanisms personalized phospholipase revisit signatures uncertainties uniform
Tagcloud (Difference) ?		1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected	2000s alloimmune ancestry basel cationic come definition deposited dqa1 endopeptidase exaggerated faithful heymann idiopathic inspired karger membranous mn nephritis nephropathy opening pathomechanisms personalized revisit signatures uncertainties uniform
Tagcloud (Intersection) ?		phospholipase