PKD1 and ACTN1

Number of citations of the paper that reports this interaction (PMID 11113628)
23

Data Source:
HPRD (in vivo, in vitro)

		PKD1	ACTN1
Gene Name		polycystic kidney disease 1 (autosomal dominant)	actinin, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Primary Cilium Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Ion Channel Binding	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding
	Biological Process	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Nitrogen Compound Metabolic Process Organelle Organization Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration JAK-STAT Cascade Heart Development Anatomical Structure Morphogenesis Single Organismal Cell-cell Adhesion Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Binding Response To Fluid Shear Stress Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium	Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		25 interactors: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 MARK2 PKD2 PTK2 PXN RGS7 SIAH1 SRC TLN1 VCL VIM	70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX
Entrez ID		5310	87
HPRD ID		03203	00020
Ensembl ID		ENSG00000008710	ENSG00000072110
Uniprot IDs		P98161	P12814
PDB IDs		1B4R	2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cytoskeleton Organization Movement Of Cell Or Subcellular Component Cell Junction Assembly Cell-cell Junction Organization Cellular Response To Organonitrogen Compound Regulation Of Cellular Component Movement Organelle Organization Cellular Response To Organic Substance Cellular Response To Indole-3-methanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Activation Regulation Of Body Fluid Levels Response To Organic Substance Response To Organonitrogen Compound Blood Coagulation Regulation Of Cell Motility Hemostasis Anatomical Structure Development Cell Development Cell Adhesion Adherens Junction Assembly Cellular Component Assembly Regulation Of Locomotion Cell-cell Junction Assembly Cell Activation Response To Wounding Generation Of Neurons Cell Morphogenesis Involved In Differentiation Locomotion Anatomical Structure Morphogenesis Cell Differentiation Neurogenesis Multicellular Organismal Development Developmental Process System Development Response To Stimulus Regulation Of Cell Migration Wound Healing Actin Filament-based Process Nervous System Development Response To Peptide Hormone Cellular Localization Response To Stress Response To Peptide Cellular Response To Peptide Hormone Stimulus Protein Complex Assembly Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development
Tagcloud ?		acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd2 polycystic polycystin progressive severity	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Difference) ?		acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd2 polycystic polycystin progressive severity	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Intersection) ?