PKD1 and PIP5K1C

Number of citations of the paper that reports this interaction (PubMedID 27775029)
55

Data Source:
BioGRID (enzymatic study)

		PKD1	PIP5K1C
Description		polycystin 1, transient receptor potential channel interacting	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
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GO Annotations	Cellular Component	Golgi Membrane Polycystin Complex Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Migrasome	Phagocytic Cup Uropod Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Endosome Membrane Endomembrane System Membrane Ruffle Membrane Cell Projection Anchoring Junction Presynapse
	Molecular Function	Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt Receptor Activity Transmembrane Transporter Binding Transcription Regulator Inhibitor Activity	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol Kinase Activity
	Biological Process	Cartilage Condensation Blood Vessel Development In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Gene Expression Regulation Of Cell Cycle Process Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Response To Fluid Shear Stress Lymph Vessel Morphogenesis Chordate Embryonic Development Skin Development Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Nitrogen Cycle Metabolic Process Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Adhesion Mitocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Exocytosis Endocytosis Phagocytosis Chemotaxis Cell Adhesion Synaptic Vesicle Exocytosis Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Synaptic Vesicle Endocytosis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases		Polycystic kidney disease	Lethal congenital contractural syndrome (LCCS)
GWAS		Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM	20 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 SMURF1 SNCA SRC TLN1 TLN2
Entrez ID		5310	23396
HPRD ID		03203	05834
Ensembl ID		ENSG00000008710	ENSG00000186111
Uniprot IDs		P98161	O60331
PDB IDs		1B4R 6A70	2G35 3H1Z 3H85
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Cell-cell Junction Cellular Response To Indole-3-methanol Cell Junction Assembly Response To Indole-3-methanol Cell Surface Receptor Signaling Pathway Cell Migration Fascia Adherens Regulation Of Cell Adhesion Signal Complex Assembly Cell Adhesion Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Vinculin Binding Cell-cell Junction Assembly ERBB Signaling Pathway Regulation Of Cell Motility Cadherin Binding Regulation Of Cell-substrate Adhesion Cellular Response To Oxygen-containing Compound Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Cell Junction Organization Integrin-mediated Signaling Pathway Cell-cell Junction Organization Regulation Of Cell Migration Extrinsic Apoptotic Signaling Pathway Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Catenin Complex Signal Transduction Zonula Adherens Scaffold Protein Binding Flotillin Complex Cellular Response To Fluid Shear Stress Neuron Projection Development Alpha-catenin Binding Supramolecular Fiber Organization Cell-cell Adhesion Intermediate Filament Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoplasm Anatomical Structure Morphogenesis Response To Fluid Shear Stress	Regulation Of Cellular Localization Positive Regulation Of Transport Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Regulation Of Protein Localization Cell Junction Organization Regulation Of Transport Intracellular Protein Transport Membrane Synaptic Vesicle Endocytosis Intracellular Protein Localization Regulation Of Protein Catabolic Process Presynaptic Endocytosis Plasma Membrane Vesicle-mediated Transport Cellular Localization Regulation Of Protein Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Endocytosis Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Organization Protein Localization To Membrane Receptor Internalization Receptor Catabolic Process Regulation Of Protein Localization To Membrane Receptor-mediated Endocytosis Protein Transport Cell Cortex Phospholipase Binding Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Vesicle-mediated Transport Positive Regulation Of Catabolic Process Protein Localization To Plasma Membrane Actin Cytoskeleton Organization Positive Regulation Of Protein Localization To Membrane Cellular Component Assembly Intracellular Transport Vesicle-mediated Transport In Synapse Cell Adhesion Import Into Cell Positive Regulation Of Protein Localization To Nucleus Ruffle Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Actin Filament-based Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Ruffle Extracellular Exosome
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