PKD1 and PTPRG

Number of citations of the paper that reports this interaction (PubMedID 21126580)
98

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PKD1	PTPRG
Description		polycystin 1, transient receptor potential channel interacting	protein tyrosine phosphatase receptor type G
Image
GO Annotations	Cellular Component	Golgi Membrane Polycystin Complex Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Migrasome	Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt Receptor Activity Transmembrane Transporter Binding Transcription Regulator Inhibitor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Identical Protein Binding
	Biological Process	Cartilage Condensation Blood Vessel Development In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Gene Expression Regulation Of Cell Cycle Process Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Response To Fluid Shear Stress Lymph Vessel Morphogenesis Chordate Embryonic Development Skin Development Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Nitrogen Cycle Metabolic Process Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Adhesion Mitocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Neuron Projection Development Neuron Projection Development Regulation Of Homophilic Cell Adhesion
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases		Polycystic kidney disease
GWAS		Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Alzheimer disease and age of onset ( 26830138) Bacteremia ( 27236921) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Breast size ( 22747683) Daytime sleep phenotypes ( 27126917) Evening vs. morning chronotype (sMEQ score) ( 32579418) Femur bone mineral density x serum urate levels interaction ( 34046847) Fuchs's corneal dystrophy ( 20825314) Ischemic stroke ( 26089329) Major depressive disorder ( 29317602 20125088) Metabolite levels ( 23823483) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) QT interval ( 20031603) Smoking initiation (ever regular vs never regular) ( 30679032) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Stroke ( 26089329) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM	3 interacting genes: DLG4 PKD1 PKD2
Entrez ID		5310	5793
HPRD ID		03203	01478
Ensembl ID		ENSG00000008710	ENSG00000144724
Uniprot IDs		P98161	P23470 Q49A02
PDB IDs		1B4R 6A70	2H4V 2HY3 2NLK 2PBN 3JXH 3QCB 3QCC 3QCD 3QCE 3QCF 3QCG 3QCH 3QCI 3QCJ 3QCK 3QCL 3QCM 3QCN 5E5R 8XQD
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Cell-cell Junction Cellular Response To Indole-3-methanol Cell Junction Assembly Response To Indole-3-methanol Cell Surface Receptor Signaling Pathway Cell Migration Fascia Adherens Regulation Of Cell Adhesion Signal Complex Assembly Cell Adhesion Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Vinculin Binding Cell-cell Junction Assembly ERBB Signaling Pathway Regulation Of Cell Motility Cadherin Binding Regulation Of Cell-substrate Adhesion Cellular Response To Oxygen-containing Compound Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Cell Junction Organization Integrin-mediated Signaling Pathway Cell-cell Junction Organization Regulation Of Cell Migration Extrinsic Apoptotic Signaling Pathway Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Catenin Complex Signal Transduction Zonula Adherens Scaffold Protein Binding Flotillin Complex Cellular Response To Fluid Shear Stress Neuron Projection Development Alpha-catenin Binding Supramolecular Fiber Organization Cell-cell Adhesion Intermediate Filament Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoplasm Anatomical Structure Morphogenesis Response To Fluid Shear Stress	Polycystin Complex Neural Tube Development Migrasome Metanephric Ascending Thin Limb Development Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Neuron Projection Arborization Epithelial Tube Morphogenesis Branching Morphogenesis Of An Epithelial Tube Regulation Of Neuron Projection Arborization Cellular Response To Metal Ion Establishment Or Maintenance Of Cell Polarity Kidney Development Metanephric Epithelium Development Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Protein Heterotetramerization Metanephric Tubule Development Metanephric Nephron Tubule Development Cation Channel Complex Renal Tubule Morphogenesis Tube Development Nephron Tubule Development Epithelium Development Embryonic Placenta Development Renal Tubule Development Protein Heterooligomerization Wnt Signaling Pathway Spinal Cord Development Placenta Blood Vessel Development Tube Morphogenesis Monoatomic Cation Channel Activity Response To Metal Ion Morphogenesis Of An Epithelium Genitalia Development Transcription Regulator Inhibitor Activity Response To Fluid Shear Stress Postsynapse Organization Detection Of Mechanical Stimulus Mesonephric Tubule Development Mesonephric Epithelium Development Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Anatomical Structure Morphogenesis Tissue Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Digestive Tract Development Ciliary Membrane Heart Looping Cell Surface Receptor Signaling Pathway Via JAK-STAT Embryonic Heart Tube Morphogenesis
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