PKD1 and OR1F1

		PKD1	OR1F1
Description		polycystin 1, transient receptor potential channel interacting	olfactory receptor family 1 subfamily F member 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Polycystin Complex Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Migrasome	Plasma Membrane Membrane
	Molecular Function	Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt Receptor Activity Transmembrane Transporter Binding Transcription Regulator Inhibitor Activity	G Protein-coupled Receptor Activity Olfactory Receptor Activity
	Biological Process	Cartilage Condensation Blood Vessel Development In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Gene Expression Regulation Of Cell Cycle Process Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Response To Fluid Shear Stress Lymph Vessel Morphogenesis Chordate Embryonic Development Skin Development Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Nitrogen Cycle Metabolic Process Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Adhesion Mitocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Expression and translocation of olfactory receptors
Drugs
Diseases		Polycystic kidney disease
GWAS		Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM
Entrez ID		5310	4992
HPRD ID		03203	09125
Ensembl ID		ENSG00000008710	ENSG00000168124
Uniprot IDs		P98161	O43749
PDB IDs		1B4R 6A70
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Cell-cell Junction Cellular Response To Indole-3-methanol Cell Junction Assembly Response To Indole-3-methanol Cell Surface Receptor Signaling Pathway Cell Migration Fascia Adherens Regulation Of Cell Adhesion Signal Complex Assembly Cell Adhesion Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Vinculin Binding Cell-cell Junction Assembly ERBB Signaling Pathway Regulation Of Cell Motility Cadherin Binding Regulation Of Cell-substrate Adhesion Cellular Response To Oxygen-containing Compound Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Cell Junction Organization Integrin-mediated Signaling Pathway Cell-cell Junction Organization Regulation Of Cell Migration Extrinsic Apoptotic Signaling Pathway Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Catenin Complex Signal Transduction Zonula Adherens Scaffold Protein Binding Flotillin Complex Cellular Response To Fluid Shear Stress Neuron Projection Development Alpha-catenin Binding Supramolecular Fiber Organization Cell-cell Adhesion Intermediate Filament Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoplasm Anatomical Structure Morphogenesis Response To Fluid Shear Stress	Calcium-independent Cell-matrix Adhesion Migrasome Polycystin Complex Lymph Vessel Morphogenesis Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Distal Tubule Morphogenesis Metanephric Nephron Tubule Morphogenesis Mitocytosis Nephric Duct Development Mesonephric Duct Development Proximal Tubule Development Metanephric Collecting Duct Development Metanephric Epithelium Development Nephron Tubule Morphogenesis Nitrogen Cycle Metabolic Process Lung Epithelium Development Protein Heterotetramerization Metanephric Tubule Development Collecting Duct Development Golgi-associated Vesicle Membrane Metanephric Nephron Tubule Development Cation Channel Complex Wnt Receptor Activity Renal Tubule Morphogenesis Mitochondrion Distribution Cartilage Condensation Cell Aggregation Nephron Tubule Development Embryonic Placenta Development Renal Tubule Development Calcium Channel Complex Protein Heterooligomerization Spinal Cord Development Placenta Blood Vessel Development Protein Export From Nucleus Establishment Of Mitochondrion Localization Monoatomic Cation Channel Activity Genitalia Development Regulation Of Mitotic Spindle Organization Neural Tube Development Transcription Regulator Inhibitor Activity Response To Fluid Shear Stress Detection Of Mechanical Stimulus Mesonephric Tubule Development Mesonephric Epithelium Development Digestive Tract Development Skin Development Ciliary Membrane
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