PKD1 and NTHL1

		PKD1	NTHL1
Description		polycystin 1, transient receptor potential channel interacting	nth like DNA glycosylase 1
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GO Annotations	Cellular Component	Golgi Membrane Polycystin Complex Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Migrasome	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt Receptor Activity Transmembrane Transporter Binding Transcription Regulator Inhibitor Activity	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity DNA Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Protein Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Cartilage Condensation Blood Vessel Development In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Gene Expression Regulation Of Cell Cycle Process Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Response To Fluid Shear Stress Lymph Vessel Morphogenesis Chordate Embryonic Development Skin Development Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Nitrogen Cycle Metabolic Process Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Adhesion Mitocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair DNA Damage Response Depyrimidination
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding
Drugs
Diseases		Polycystic kidney disease
GWAS		Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Longevity ( 20834067)
Interacting Genes		31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM	4 interacting genes: ERCC5 PCNA SRPK2 TP53
Entrez ID		5310	4913
HPRD ID		03203	04039
Ensembl ID		ENSG00000008710	ENSG00000065057
Uniprot IDs		P98161	E5KTI5 P78549
PDB IDs		1B4R 6A70	7RDS 7RDT
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Cell-cell Junction Cellular Response To Indole-3-methanol Cell Junction Assembly Response To Indole-3-methanol Cell Surface Receptor Signaling Pathway Cell Migration Fascia Adherens Regulation Of Cell Adhesion Signal Complex Assembly Cell Adhesion Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Vinculin Binding Cell-cell Junction Assembly ERBB Signaling Pathway Regulation Of Cell Motility Cadherin Binding Regulation Of Cell-substrate Adhesion Cellular Response To Oxygen-containing Compound Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Cell Junction Organization Integrin-mediated Signaling Pathway Cell-cell Junction Organization Regulation Of Cell Migration Extrinsic Apoptotic Signaling Pathway Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Catenin Complex Signal Transduction Zonula Adherens Scaffold Protein Binding Flotillin Complex Cellular Response To Fluid Shear Stress Neuron Projection Development Alpha-catenin Binding Supramolecular Fiber Organization Cell-cell Adhesion Intermediate Filament Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoplasm Anatomical Structure Morphogenesis Response To Fluid Shear Stress	Response To UV Nucleotide-excision Repair Response To Light Stimulus Cellular Response To UV Response To Radiation Transcription-coupled Nucleotide-excision Repair Cellular Response To Light Stimulus Negative Regulation Of Mitophagy Response To UV-C Base-excision Repair, AP Site Formation DNA Repair Cellular Response To Radiation Response To Stress Replication Fork DNA Metabolic Process 14-3-3 Protein Binding DNA Damage Response Negative Regulation Of Macroautophagy Heart Development Nucleic Acid Metabolic Process Regulation Of Mitophagy DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Autophagy Of Mitochondrion Protein-containing Complex Binding Mitophagy Response To Oxidative Stress Receptor Tyrosine Kinase Binding Regulation Of Cell Cycle Cellular Response To Xenobiotic Stimulus Regulation Of Proteolysis Damaged DNA Binding Positive Regulation Of Neuron Apoptotic Process Interferon-mediated Signaling Pathway Autophagy Of Mitochondrion PCNA Complex Replisome Metanephric Distal Tubule Morphogenesis Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Tetramerization Positive Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Amino Acid PCNA-p21 Complex
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