PKD1 and COL1A1

Number of citations of the paper that reports this interaction (PubMedID 11752017)
0

Data Source:
BioGRID (pull down)

		PKD1	COL1A1
Description		polycystin 1, transient receptor potential channel interacting	collagen type I alpha 1 chain
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GO Annotations	Cellular Component	Golgi Membrane Polycystin Complex Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Migrasome	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type I Trimer Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Secretory Granule Extracellular Matrix
	Molecular Function	Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt Receptor Activity Transmembrane Transporter Binding Transcription Regulator Inhibitor Activity	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Cartilage Condensation Blood Vessel Development In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Gene Expression Regulation Of Cell Cycle Process Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Response To Fluid Shear Stress Lymph Vessel Morphogenesis Chordate Embryonic Development Skin Development Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Nitrogen Cycle Metabolic Process Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Adhesion Mitocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Skeletal System Development Ossification Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Response To Nutrient Visual Perception Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Mechanical Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Collagen Fibril Organization Positive Regulation Of Cell Migration Response To Nutrient Levels Response To Estradiol Response To Insulin Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Response To Hydrogen Peroxide Response To Peptide Hormone Skin Development Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of DNA-templated Transcription Animal Organ Development Response To Steroid Hormone Skeletal System Morphogenesis Embryonic Skeletal System Development System Development Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Response To Fluoride Cellular Response To Fluoride
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	GPVI-mediated activation cascade Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling RUNX2 regulates osteoblast differentiation Collagen chain trimerization Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V Developmental Lineage of Pancreatic Ductal Cells
Drugs			Collagenase clostridium histolyticum Halofuginone Clove oil Vonicog alfa Von Willebrand factor human
Diseases		Polycystic kidney disease	Osteogenesis imperfecta Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Infantile cortical hyperostosis; Caffey disease
GWAS		Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)	Blood cell traits (multivariate analysis) ( 31080455) Breast cancer ( 17903305) Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Response to taxane treatment (docetaxel) ( 23006423)
Interacting Genes		31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM	44 interacting genes: ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 CDC42 COL18A1 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 KEAP1 LAIR1 MAG MATN2 MCPH1 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI TGM2 THBS1 TMPRSS6 TNFAIP3 TXN UBC VWF
Entrez ID		5310	1277
HPRD ID		03203	00362
Ensembl ID		ENSG00000008710	ENSG00000108821
Uniprot IDs		P98161	P02452
PDB IDs		1B4R 6A70	1Q7D 2LLP 3EJH 3GXE 5CTD 5CTI 5CVA 5CVB 5K31 5OU8 5OU9 7E7B 7E7D
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Cell-cell Junction Cellular Response To Indole-3-methanol Cell Junction Assembly Response To Indole-3-methanol Cell Surface Receptor Signaling Pathway Cell Migration Fascia Adherens Regulation Of Cell Adhesion Signal Complex Assembly Cell Adhesion Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Vinculin Binding Cell-cell Junction Assembly ERBB Signaling Pathway Regulation Of Cell Motility Cadherin Binding Regulation Of Cell-substrate Adhesion Cellular Response To Oxygen-containing Compound Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Cell Junction Organization Integrin-mediated Signaling Pathway Cell-cell Junction Organization Regulation Of Cell Migration Extrinsic Apoptotic Signaling Pathway Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Catenin Complex Signal Transduction Zonula Adherens Scaffold Protein Binding Flotillin Complex Cellular Response To Fluid Shear Stress Neuron Projection Development Alpha-catenin Binding Supramolecular Fiber Organization Cell-cell Adhesion Intermediate Filament Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoplasm Anatomical Structure Morphogenesis Response To Fluid Shear Stress	Collagen Binding Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Space Positive Regulation Of Cell Migration Basement Membrane Positive Regulation Of Cell Motility Extracellular Matrix Binding Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Locomotion Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Cell Motility Response To Wounding Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Locomotion Developmental Process Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Cell-matrix Adhesion Platelet Alpha Granule Lumen Regulation Of Cell Communication Regulation Of Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Endodermal Cell Differentiation Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell-substrate Adhesion Extracellular Exosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Regulation Of Cell-substrate Adhesion Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Signaling Integrin Binding Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Cell Surface Regulation Of MAPK Cascade Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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