PKD1 and SOX17

  • Data Source: HiPPIP (Novel)

PKD1

SOX17

Name polycystin 1, transient receptor potential channel interacting SRY-box transcription factor 17
Structure PDB 1B4R PDB 2YUL
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Diseases
GWAS
  • Appendicular lean mass ( 33097823 )
  • Dilated cardiomyopathy ( 33677556 )
  • Estimated glomerular filtration rate ( 31451708 )
  • Estimated glomerular filtration rate in non-diabetics ( 31451708 )
  • Heel bone mineral density ( 30598549 )
  • Height ( 28552196 )
  • High light scatter reticulocyte count ( 32888494 )
  • Hypertrophic cardiomyopathy (MTAG) ( 33495596 )
  • Low hand grip strength (60 years and older) (EWGSOP) ( 33510174 )
  • Major depressive disorder ( 29317602 )
  • Neutrophil count ( 32888494 )
  • Systolic blood pressure ( 30578418 )
  • Waist circumference adjusted for body mass index ( 34021172 )
  • Apolipoprotein B levels ( 32203549 )
  • Cholesterol, total ( 24097068 )
  • Factor VIII levels ( 30586737 )
  • Intracranial aneurysm ( 20364137 33199917 18997786 )
  • LDL cholesterol ( 24097068 )
  • LDL cholesterol levels ( 28334899 30698716 32203549 )
  • LDL cholesterol levels in current drinkers ( 30698716 )
  • LDL cholesterol levels in HIV infection ( 33109212 )
  • LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 )
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 )
  • Lung cancer ( 28604730 )
  • Lung cancer in ever smokers ( 28604730 )
  • Pulmonary arterial hypertension ( 30527956 )
  • Total cholesterol levels ( 28334899 )
Novel Interactors 9 novel interactors: NADSYN1 NTHL1 NTN3 OR1F1 PDPK1 PPL RIGI RPL3L SOX17 1 novel interactors: PKD1
Interacting Genes 31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM 4 interacting genes: CTNNB1 HNF1B NFIC NFIX
Entrez ID 5310 64321
HPRD ID 03203 18085
Ensembl ID ENSG00000008710 ENSG00000164736
Uniprot IDs P98161 Q9H6I2
PDB IDs 1B4R 6A70 2YUL 4A3N
GO Terms Enriched among Interactors