PIK3C3 and YWHAQ

Number of citations of the paper that reports this interaction (PubMedID 7479742)
48

Data Source:
BioGRID (pull down)

		PIK3C3	YWHAQ
Description		phosphatidylinositol 3-kinase catalytic subunit type 3	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
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GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Autophagosome Peroxisome Cytosol Plasma Membrane Axoneme Membrane Midbody Phagocytic Vesicle Membrane Cytoplasmic Vesicle Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome Phagocytic Vesicle Postsynapse Presynaptic Endosome Postsynaptic Endosome Glutamatergic Synapse GABA-ergic Synapse	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Phosphatidylinositol Kinase Activity	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding
	Biological Process	Autophagosome Assembly Pexophagy Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Endosome Organization Cellular Response To Starvation Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Protein Processing Regulation Of Cytokinesis Protein Localization To Phagophore Assembly Site Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Response To L-leucine Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Host-mediated Activation Of Viral Genome Replication Early Endosome To Late Endosome Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Synaptic Vesicle Endocytosis Cell Division Type II Interferon-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Autophagosome Maturation Positive Regulation Of Protein Lipidation	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription
Pathways		PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs		N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide GSK-1059615	Phenethyl Isothiocyanate
Diseases
GWAS		Adult body size ( 32376654) Blood trace element (Zn levels) ( 23720494) Body size at age 10 ( 32376654) Frailty index ( 34431594) General risk tolerance (MTAG) ( 30643258) Major depressive disorder (MTAG) ( 33479212) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966) Walking pace ( 33128006)	Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)
Interacting Genes		12 interacting genes: CALM1 CASP8 FBXL20 KLHL20 OTUD7B PDPK1 PIK3R4 PITPNA STYK1 UBE3C YWHAG YWHAQ	216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2
Entrez ID		5289	10971
HPRD ID		04009	00886
Ensembl ID		ENSG00000078142	ENSG00000134308
Uniprot IDs		A8MYT4 B4DPV9 Q8NEB9	P27348
PDB IDs		3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6HOG 6HOH 6I3U 6YKG 7BL1 7RSJ 7RSP 7RSV 8RXR 8SOR 9C82 9E4V 9MHF 9MHG 9MHH	2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Protein Catabolic Process Proteolysis Substantia Nigra Development Intracellular Signal Transduction Cytosol Protein Metabolic Process Protein Modification Process 3-phosphoinositide-dependent Protein Kinase Activity Protein Localization To Lysosome Macromolecule Catabolic Process Cellular Response To Glucose Starvation Modification-dependent Protein Catabolic Process Protein Targeting SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Type II Interferon Binding Nucleus-vacuole Junction Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Monoatomic Ion Transmembrane Transport Neural Nucleus Development Protein Polyubiquitination Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Canonical NF-kappaB Signal Transduction Protein K33-linked Ubiquitination Intracellular Signaling Cassette Regulation Of Cytokinesis Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Canonical NF-kappaB Signal Transduction Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Autophagosome Assembly Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Insulin Stimulus Quaternary Ammonium Group Binding Post-translational Protein Modification Positive Regulation Of TOR Signaling Protein Localization To Vacuole Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Protein Kinase C Inhibitor Activity Autophagosome Organization Phosphatidylinositol Biosynthetic Process Negative Regulation Of Transmembrane Transport	Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus
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