PIK3C3 and PIK3R4

Number of citations of the paper that reports this interaction (PMID 8999962)
43

Data Source:
HPRD (in vivo, in vitro)

		PIK3C3	PIK3R4
Gene Name		phosphatidylinositol 3-kinase, catalytic subunit type 3	phosphoinositide-3-kinase, regulatory subunit 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Late Endosome Cytosol Axoneme Phosphatidylinositol 3-kinase Complex Membrane Midbody Phagocytic Vesicle	Nuclear Pore Late Endosome Cytosol Axoneme Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Nucleus-vacuole Junction
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Autophagic Vacuole Assembly Cytokinesis Toll-like Receptor Signaling Pathway Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endosome Organization Insulin Receptor Signaling Pathway Protein Processing Toll-like Receptor 9 Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Response To Leucine Small Molecule Metabolic Process Early Endosome To Late Endosome Transport Innate Immune Response Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Regulation Of Protein Secretion	Toll-like Receptor Signaling Pathway Protein Phosphorylation Protein Targeting To Vacuole Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Macroautophagy Peroxisome Degradation Toll-like Receptor 9 Signaling Pathway Small Molecule Metabolic Process Innate Immune Response Late Endosome To Vacuole Transport
Pathways		Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Insulin receptor signalling cascade Metabolism of lipids and lipoproteins IRS-mediated signalling IRS-related events IGF1R signaling cascade Synthesis of PIPs at the late endosome membrane IRS-related events triggered by IGF1R Toll-Like Receptors Cascades IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Toll Like Receptor 9 (TLR9) Cascade Phospholipid metabolism PI3K Cascade PI3K Cascade Innate Immune System PI Metabolism Signaling by Insulin receptor	Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Insulin receptor signalling cascade Metabolism of lipids and lipoproteins IRS-mediated signalling IRS-related events IGF1R signaling cascade Synthesis of PIPs at the late endosome membrane IRS-related events triggered by IGF1R Toll-Like Receptors Cascades IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Toll Like Receptor 9 (TLR9) Cascade Phospholipid metabolism PI3K Cascade PI3K Cascade Innate Immune System PI Metabolism Signaling by Insulin receptor
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: CALM1 PIK3R4 PITPNA SUMO1 YWHAG YWHAQ	4 interactors: BECN1 MAPRE1 PIK3C3 YWHAB
Entrez ID		5289	30849
HPRD ID		04009	04010
Ensembl ID			ENSG00000196455
Uniprot IDs		A8MYT4 Q8NEB9	Q99570
PDB IDs		3IHY 3LS8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Membrane Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Cellular Localization Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Targeting Regulation Of Intracellular Transport Cellular Protein Localization Midbrain Development Regulation Of Mitochondrion Organization Cellular Response To Organic Substance Positive Regulation Of Transport Protein Localization Establishment Of Localization In Cell Regulation Of Protein Localization Innate Immune Response Peroxisome Degradation Response To Organonitrogen Compound Negative Regulation Of Cellular Metabolic Process Regulation Of Immune Response Intrinsic Apoptotic Signaling Pathway PML Body Organization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Apoptotic Signaling Pathway Intracellular Protein Transport Nervous System Development Response To Hormone Cellular Response To Insulin Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Protein Localization To Nuclear Pore Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Regulation Of Innate Immune Response Response To Organic Substance Protein Localization To Nuclear Envelope Late Endosome To Vacuole Transport Response To Stimulus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Anatomical Structure Development Transport Response To Insulin Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Protein Phosphorylation Signal Transduction	Autophagic Vacuole Assembly Cell Division Macroautophagy Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Vacuole Organization Cellular Localization Cytokinesis Cellular Response To Aluminum Ion Cellular Response To Starvation Regulation Of Organelle Organization Insulin Receptor Signaling Pathway Autophagy Positive Regulation Of Mitochondrion Degradation CVT Pathway Cell Cycle Process Cellular Response To Nutrient Levels Response To Starvation Endosomal Transport Positive Regulation Of Microtubule Plus-end Binding Cellular Response To Extracellular Stimulus Cellular Response To Insulin Stimulus Defense Response Cell Cycle Cellular Protein Localization Response To Aluminum Ion Response To Insulin Negative Regulation Of Protein Dephosphorylation Cellular Response To Peptide Hormone Stimulus Intracellular Transport Response To Leucine Late Endosome To Vacuole Transport Cellular Response To Peptide Protein Localization To Microtubule Regulation Of Mitochondrion Degradation Positive Regulation Of Organelle Organization Response To External Stimulus Protein Targeting Cellular Response To Organic Substance Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Cellular Component Organization Response To Peptide Hormone Response To Extracellular Stimulus Immune Response-regulating Signaling Pathway Establishment Of Localization In Cell Cellular Response To Organonitrogen Compound Organelle Assembly Positive Regulation Of Macroautophagy
Tagcloud ?		autophagosome autophagy cdtb coregulators cyld cytolethal deltas destroys distending distension enterica esr1 functionality imported internalized javiana lc3 macrophages nontyphoidal nts salmonella serovar serovars spread toxin typhi typhimurium vacuolization wt	actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 kalrn l576 melanomas mined ngs nras ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557
Tagcloud (Difference) ?		autophagosome autophagy cdtb coregulators cyld cytolethal deltas destroys distending distension enterica esr1 functionality imported internalized javiana lc3 macrophages nontyphoidal nts salmonella serovar serovars spread toxin typhi typhimurium vacuolization wt	actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 kalrn l576 melanomas mined ngs nras ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557
Tagcloud (Intersection) ?