PDPK1 and PKN1

Number of citations of the paper that reports this interaction (PMID 10764742)
39

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		PDPK1	PKN1
Gene Name		3-phosphoinositide dependent protein kinase 1	protein kinase N1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Cytoplasmic Membrane-bounded Vesicle Cell Projection	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow
	Molecular Function	Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Insulin Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Protein Kinase Binding Phospholipase Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding
	Biological Process	Type B Pancreatic Cell Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Endothelial Cell Migration Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Peptidyl-threonine Phosphorylation Calcium-mediated Signaling Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway T Cell Costimulation Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mast Cell Degranulation Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Focal Adhesion Assembly T Cell Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Extrinsic Apoptotic Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of PKB Platelet Aggregation (Plug Formation) Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation PI3K/AKT activation PI-3K cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling TCR signaling Signaling by VEGF Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Transmission across Chemical Synapses Downstream TCR signaling Activation of PKB Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R VEGFR2 mediated cell proliferation G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling RSK activation Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Activation of NMDA receptor upon glutamate binding and postsynaptic events Signaling by Insulin receptor Innate Immune System Post NMDA receptor activation events Signalling by NGF Insulin receptor signalling cascade CTLA4 inhibitory signaling Integrin alphaIIb beta3 signaling IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade PI3K Cascade
Drugs		Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine 3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione Staurosporine Rbt205 Inhibitor Phosphonoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AKT1 AKT2 AKT3 AKTIP APP BLMH C2orf44 CARD11 CDAN1 DDIT4 FAM213B GIT1 HSP90AA1 ILK IRS1 ITGB3 KATNBL1 LUC7L2 MAPK8 MTOR PAK1 PEA15 PHAX PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SLC9A3R2 SMARCB1 SOCS3 SRC SRPK1 STRAP TCAP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133	40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282
Entrez ID		5170	5585
HPRD ID		05556	03019
Ensembl ID		ENSG00000140992	ENSG00000123143
Uniprot IDs		E9PER6 O15530	Q16512
PDB IDs		1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1	1CXZ 1URF 2RMK
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Apoptotic Process Programmed Cell Death Regulation Of Signaling Intracellular Signal Transduction Cell Death Death Innate Immune Response Cellular Protein Modification Process Response To Stress Regulation Of Cellular Response To Insulin Stimulus Regulation Of Glucose Import Regulation Of Glucose Transport Phosphate-containing Compound Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell Motility Defense Response Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Locomotion Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cellular Component Movement Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Metabolic Process Cellular Response To Peptide Cellular Response To Organic Substance Signal Transduction Cellular Response To Stimulus Peptidyl-threonine Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Platelet Activation	Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		amplified bcl2l1 caspase caspases executioner ikbkb kinome mb231 mb468 mesenchymal nodes nonkinases phosphatases phosphatome r1 r2 regulators representing screens sensitivities sensitizes sineg sirna skbr3 src subset t47d tnbc trail	accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5
Tagcloud (Difference) ?		amplified bcl2l1 caspase caspases executioner ikbkb kinome mb231 mb468 mesenchymal nodes nonkinases phosphatases phosphatome r1 r2 regulators representing screens sensitivities sensitizes sineg sirna skbr3 src subset t47d tnbc trail	accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5
Tagcloud (Intersection) ?