PDPK1 and ITGB3

Number of citations of the paper that reports this interaction (PubMedID 10896934)
0

Data Source:
HPRD (in vitro)

		PDPK1	ITGB3
Description		3-phosphoinositide dependent protein kinase 1	integrin subunit beta 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytoplasmic Vesicle Cell Projection Anchoring Junction	Ruffle Nucleus Nucleoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Filopodium Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Protein-containing Complex Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Melanosome Cell Projection Receptor Complex Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Alpha9-beta1 Integrin-ADAM8 Complex Synaptic Membrane Glycinergic Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Phospholipase Binding Protein Serine Kinase Activity	Virus Receptor Activity Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Protein Kinase C Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding Enzyme Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Neuregulin Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Type B Pancreatic Cell Development Protein Phosphorylation Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Calcium-mediated Signaling Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Intracellular Signaling Cassette Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Leukocyte Migration Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Blood Coagulation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Negative Regulation Of Lipid Storage Negative Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Smooth Muscle Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Negative Regulation Of Lipid Transport Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Wound Healing, Spreading Of Epidermal Cells Response To Platelet-derived Growth Factor Cellular Response To Platelet-derived Growth Factor Stimulus Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Apoptotic Cell Clearance Regulation Of Bone Resorption Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Developmental Process Negative Chemotaxis Regulation Of Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Serotonin Uptake Angiogenesis Involved In Wound Healing Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Glomerular Mesangial Cell Proliferation Blood Coagulation, Fibrin Clot Formation Maintenance Of Postsynaptic Specialization Structure Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Trophoblast Cell Migration Regulation Of Extracellular Matrix Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Activation of AKT2 Downstream TCR signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated NF-kB activation Integrin signaling CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma RSK activation VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases activate PKNs Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Platelet degranulation Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine Bisindolylmaleimide VIII Staurosporine Bisindolylmaleimide I Dexfosfoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE Fostamatinib	Abciximab Eptifibatide Antithymocyte immunoglobulin (rabbit) Levothyroxine Tirofiban Resveratrol Lefradafiban LM-609 Fradafiban Ferric maltol
Diseases			Allograft rejection Glanzmann thrombasthenia
GWAS		Hip circumference adjusted for BMI ( 34021172)	Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 33713608) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		68 interacting genes: AKT1 AKT2 AKT3 AKTIP APBB3 APP BLMH CARD11 CDAN1 CSK CSNK1D CUL3 DDIT4 GIT1 GSK3B HSP90AA1 ILK IRS1 ITGB3 KATNBL1 KLHL20 LUC7L2 MAPK8 MTOR NHERF2 PAK1 PEA15 PHAX PIK3C3 PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PRXL2B PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SMARCB1 SOCS3 SPOP SRC SRPK1 STRAP TCAP UBC UBE2I WDCP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133	50 interacting genes: AKT1 ANGPTL3 APP CAPN1 CD36 CDK1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGFR1 FGG FLNA FLNB FN1 GRIA2 HRAS ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR MAPK3 MIIP NID1 NUMB P2RY2 P4HB PDGFRA PDGFRB PDK1 PDPK1 PECAM1 PLA2G2A PLA2G4A PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN
Entrez ID		5170	3690
HPRD ID		05556	01428
Ensembl ID		ENSG00000140992	ENSG00000259207
Uniprot IDs		E9PER6 O15530	P05106
PDB IDs		1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LVM 5LVN 5LVO 5LVP 5MRD 6WJQ 8DQT	1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1S4X 1TYE 1U8C 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2MTP 2N9Y 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4Z7N 4Z7O 4Z7Q 5HDB 6AVQ 6AVR 6AVU 6BXB 6BXF 6BXJ 6CKB 6MK0 6MSL 6MSU 6NAJ 6V4P 7KN0 7L8P 7LA4 7TCT 7TD8 7THO 7TMZ 7TPD 7U60 7U9F 7U9V 7UBR 7UCY 7UDG 7UDH 7UE0 7UFH 7UH8 7UJE 7UJK 7UK9 7UKO 7UKP 7UKT 8GCD 8GCE 8IJ5 8T2U 8T2V 8XEI 8XEK 8XEL 8XEN 8XER 8XEZ 8XF6 8XFG 8XFO 9AXL 9DEQ 9DER
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Phosphorylation Phosphorylation Intracellular Signal Transduction ATP Binding Protein Modification Process Cytosol Cellular Response To Peptide Hormone Stimulus Nucleotide Binding Cellular Response To Oxygen-containing Compound Protein Metabolic Process Cellular Response To Hormone Stimulus Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cellular Response To Insulin Stimulus Nucleus TOR Signaling Transferase Activity TORC1 Signaling Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Response To Peptide Hormone Negative Regulation Of Cellular Response To Insulin Stimulus Response To Hormone Phosphate-containing Compound Metabolic Process Signal Transduction Regulation Of Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Insulin Stimulus Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Regulation Of TOR Signaling Regulation Of Signaling Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Fluid Shear Stress Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Focal Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Integrin-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cell Adhesion Integrin Binding Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell-substrate Adhesion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Angiogenesis Cell-matrix Adhesion Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Anchoring Junction Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction External Side Of Plasma Membrane Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Protein Autophosphorylation Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?