PDPK1 and ITGB3

Number of citations of the paper that reports this interaction (PMID 10896934)
16

Data Source:
HPRD (in vitro)

		PDPK1	ITGB3
Gene Name		3-phosphoinositide dependent protein kinase 1	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Cytoplasmic Membrane-bounded Vesicle Cell Projection	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Melanosome Receptor Complex Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Insulin Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Protein Kinase Binding Phospholipase Binding	Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding
	Biological Process	Type B Pancreatic Cell Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Endothelial Cell Migration Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Peptidyl-threonine Phosphorylation Calcium-mediated Signaling Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway T Cell Costimulation Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mast Cell Degranulation Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Focal Adhesion Assembly T Cell Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Extrinsic Apoptotic Signaling Pathway	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Protein Folding Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Growth Cell Migration Platelet Activation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Regulation Of Bone Resorption Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Leukocyte Migration Negative Chemotaxis Angiogenesis Involved In Wound Healing Platelet Aggregation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of PKB Platelet Aggregation (Plug Formation) Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation PI3K/AKT activation PI-3K cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling TCR signaling Signaling by VEGF Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Transmission across Chemical Synapses Downstream TCR signaling Activation of PKB Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R VEGFR2 mediated cell proliferation G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling RSK activation Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Activation of NMDA receptor upon glutamate binding and postsynaptic events Signaling by Insulin receptor Innate Immune System Post NMDA receptor activation events Signalling by NGF Insulin receptor signalling cascade CTLA4 inhibitory signaling Integrin alphaIIb beta3 signaling IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade PI3K Cascade	Signal transduction by L1 Axon guidance Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation Non-integrin membrane-ECM interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine 3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione Staurosporine Rbt205 Inhibitor Phosphonoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE	Abciximab Eptifibatide Antithymocyte globulin Tirofiban
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AKT1 AKT2 AKT3 AKTIP APP BLMH C2orf44 CARD11 CDAN1 DDIT4 FAM213B GIT1 HSP90AA1 ILK IRS1 ITGB3 KATNBL1 LUC7L2 MAPK8 MTOR PAK1 PEA15 PHAX PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SLC9A3R2 SMARCB1 SOCS3 SRC SRPK1 STRAP TCAP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133	40 interactors: AKT1 ANGPTL3 CAPN1 CD36 CIB1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGG FLNA FLNB FN1 ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR NID1 NUMB P2RY2 PDGFRA PDGFRB PDPK1 PECAM1 PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN
Entrez ID		5170	3690
HPRD ID		05556	01428
Ensembl ID		ENSG00000140992	ENSG00000259207
Uniprot IDs		E9PER6 O15530	P05106
PDB IDs		1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1	1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Apoptotic Process Programmed Cell Death Regulation Of Signaling Intracellular Signal Transduction Cell Death Death Innate Immune Response Cellular Protein Modification Process Response To Stress Regulation Of Cellular Response To Insulin Stimulus Regulation Of Glucose Import Regulation Of Glucose Transport Phosphate-containing Compound Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell Motility Defense Response Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Locomotion Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cellular Component Movement Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Metabolic Process Cellular Response To Peptide Cellular Response To Organic Substance Signal Transduction Cellular Response To Stimulus Peptidyl-threonine Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Platelet Activation	Platelet Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Blood Coagulation Positive Regulation Of Cellular Component Movement Cell Adhesion Hemostasis Positive Regulation Of Locomotion Regulation Of Cell Migration Wound Healing Positive Regulation Of Phosphorylation Regulation Of Cell-substrate Adhesion Regulation Of Cell Motility Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Regulation Of Phosphorylation Cell-matrix Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Activation Blood Vessel Development Positive Regulation Of Protein Modification Process Signal Transduction Regulation Of Protein Phosphorylation Vasculature Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Metabolic Process Cell Communication Positive Regulation Of Kinase Activity Locomotion Anatomical Structure Morphogenesis Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Intracellular Signal Transduction Platelet Degranulation
Tagcloud ?		amplified bcl2l1 caspase caspases executioner ikbkb kinome mb231 mb468 mesenchymal nodes nonkinases phosphatases phosphatome r1 r2 regulators representing screens sensitivities sensitizes sineg sirna skbr3 src subset t47d tnbc trail	a4 acp5 apb b4 blt1 blt2 conclusionsin crac ctsk cytochemical erosion hydrolase introductionbone leukotriene leukotrienes lipoxygenase ltb4 manuscript methodswe mmp9 nfatc1 nucleated osteoclast osteoclasts pbmcs phospholipase resorbing resultsour u73122
Tagcloud (Difference) ?		amplified bcl2l1 caspase caspases executioner ikbkb kinome mb231 mb468 mesenchymal nodes nonkinases phosphatases phosphatome r1 r2 regulators representing screens sensitivities sensitizes sineg sirna skbr3 src subset t47d tnbc trail	a4 acp5 apb b4 blt1 blt2 conclusionsin crac ctsk cytochemical erosion hydrolase introductionbone leukotriene leukotrienes lipoxygenase ltb4 manuscript methodswe mmp9 nfatc1 nucleated osteoclast osteoclasts pbmcs phospholipase resorbing resultsour u73122
Tagcloud (Intersection) ?