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PDPK1 and PRKCI
Number of citations of the paper that reports this interaction (PubMedID
31980649
)
68
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vivo, two hybrid)
PDPK1
PRKCI
Description
3-phosphoinositide dependent protein kinase 1
protein kinase C iota
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Postsynaptic Density
Membrane
Cytoplasmic Vesicle
Cell Projection
Anchoring Junction
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Brush Border
Bicellular Tight Junction
Cilium
Microtubule Cytoskeleton
Membrane
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Apical Part Of Cell
Extracellular Exosome
Tight Junction
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
PAR Polarity Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
3-phosphoinositide-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Phospholipase Binding
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Phospholipid Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Type B Pancreatic Cell Development
Protein Phosphorylation
Hyperosmotic Response
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Endothelial Cell Migration
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Calcium-mediated Signaling
Actin Cytoskeleton Organization
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
T Cell Costimulation
Cellular Response To Insulin Stimulus
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Mast Cell Degranulation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Intracellular Signaling Cassette
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Apoptotic Process
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Establishment Of Cell Polarity
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of D-glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Cellular Response To Chemical Stress
Response To Interleukin-1
Protein Localization To Plasma Membrane
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
KEAP1-NFE2L2 pathway
Drugs
Celecoxib
Inositol 1,3,4,5-Tetrakisphosphate
7-Hydroxystaurosporine
Bisindolylmaleimide VIII
Staurosporine
Bisindolylmaleimide I
Dexfosfoserine
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Fostamatinib
Tamoxifen
Staurosporine
Bisindolylmaleimide I
Dequalinium
Benzoyl peroxide
Fostamatinib
Diseases
GWAS
Hip circumference adjusted for BMI (
34021172
)
Aspartate aminotransferase levels (
33547301
)
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31511532
31630189
)
Interacting Genes
68 interacting genes:
AKT1
AKT2
AKT3
AKTIP
APBB3
APP
BLMH
CARD11
CDAN1
CSK
CSNK1D
CUL3
DDIT4
GIT1
GSK3B
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
KLHL20
LUC7L2
MAPK8
MTOR
NHERF2
PAK1
PEA15
PHAX
PIK3C3
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PRXL2B
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SMARCB1
SOCS3
SPOP
SRC
SRPK1
STRAP
TCAP
UBC
UBE2I
WDCP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
51 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
Entrez ID
5170
5584
HPRD ID
05556
02105
Ensembl ID
ENSG00000140992
ENSG00000163558
Uniprot IDs
E9PER6
O15530
P41743
PDB IDs
1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
4CT1
4CT2
4RQK
4RQV
4RRV
4XX9
5ACK
5HKM
5HNG
5HO7
5HO8
5LVL
5LVM
5LVN
5LVO
5LVP
5MRD
6WJQ
8DQT
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
8R3X
8R3Y
Enriched GO Terms of Interacting Partners
?
Protein Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Kinase Activity
Protein Phosphorylation
Phosphorylation
Intracellular Signal Transduction
ATP Binding
Protein Modification Process
Cytosol
Cellular Response To Peptide Hormone Stimulus
Nucleotide Binding
Cellular Response To Oxygen-containing Compound
Protein Metabolic Process
Cellular Response To Hormone Stimulus
Cytoplasm
Diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Cellular Response To Insulin Stimulus
Nucleus
TOR Signaling
Transferase Activity
TORC1 Signaling
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Response To Peptide Hormone
Negative Regulation Of Cellular Response To Insulin Stimulus
Response To Hormone
Phosphate-containing Compound Metabolic Process
Signal Transduction
Regulation Of Signal Transduction
Negative Regulation Of TOR Signaling
Regulation Of Generation Of Precursor Metabolites And Energy
Cellular Response To Insulin Stimulus
Peptidyl-serine Phosphorylation
Response To Fluid Shear Stress
Regulation Of TOR Signaling
Regulation Of Signaling
Negative Regulation Of Apoptotic Process
Regulation Of Cell Communication
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Programmed Cell Death
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Signal Transduction
Cellular Response To Fluid Shear Stress
Regulation Of Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Signal Transduction
Cytoplasm
Cytosol
Intracellular Signaling Cassette
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Localization
Intracellular Signal Transduction
Immune System Process
PAR Polarity Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Regulation Of Protein Localization
Positive Regulation Of Biosynthetic Process
Regulation Of Multicellular Organismal Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Regulation Of Gene Expression
Positive Regulation Of Protein Localization
Regulation Of Immune Response
Plasma Membrane
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Projection Organization
Regulation Of Programmed Cell Death
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Organelle Organization
Negative Regulation Of Programmed Cell Death
Protein Serine/threonine Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Immune System Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Apoptotic Process
Establishment Or Maintenance Of Cell Polarity
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Cell Projection Organization
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Regulation Of Primary Metabolic Process
Regulation Of Innate Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
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