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PDPK1 and RPS6KA1
Number of citations of the paper that reports this interaction (PubMedID
10480933
)
0
Data Source:
HPRD
(in vitro, in vivo)
PDPK1
RPS6KA1
Description
3-phosphoinositide dependent protein kinase 1
ribosomal protein S6 kinase A1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Postsynaptic Density
Membrane
Cytoplasmic Vesicle
Cell Projection
Anchoring Junction
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Synapse
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
3-phosphoinositide-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Phospholipase Binding
Protein Serine Kinase Activity
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Type B Pancreatic Cell Development
Protein Phosphorylation
Hyperosmotic Response
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Endothelial Cell Migration
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Calcium-mediated Signaling
Actin Cytoskeleton Organization
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
T Cell Costimulation
Cellular Response To Insulin Stimulus
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Mast Cell Degranulation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Intracellular Signaling Cassette
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Apoptotic Process
Protein Phosphorylation
Signal Transduction
Chemical Synaptic Transmission
Positive Regulation Of Cell Growth
Negative Regulation Of TOR Signaling
Intracellular Signal Transduction
TORC1 Signaling
Negative Regulation Of Apoptotic Process
Regulation Of Translation In Response To Stress
Positive Regulation Of Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Proliferation
Positive Regulation Of Hepatic Stellate Cell Activation
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Celecoxib
Inositol 1,3,4,5-Tetrakisphosphate
7-Hydroxystaurosporine
Bisindolylmaleimide VIII
Staurosporine
Bisindolylmaleimide I
Dexfosfoserine
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Fostamatinib
Purvalanol A
Fostamatinib
Diseases
GWAS
Hip circumference adjusted for BMI (
34021172
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Fasting plasma glucose (
31932636
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
32888494
)
Mean corpuscular volume (
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
30108155
)
White blood cell count (
32888494
)
Interacting Genes
68 interacting genes:
AKT1
AKT2
AKT3
AKTIP
APBB3
APP
BLMH
CARD11
CDAN1
CSK
CSNK1D
CUL3
DDIT4
GIT1
GSK3B
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
KLHL20
LUC7L2
MAPK8
MTOR
NHERF2
PAK1
PEA15
PHAX
PIK3C3
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PRXL2B
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SMARCB1
SOCS3
SPOP
SRC
SRPK1
STRAP
TCAP
UBC
UBE2I
WDCP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
88 interacting genes:
ARHGEF11
ARHGEF12
ATM
ATXN3
BAD
CARHSP1
CCT4
CDKN1B
CEBPB
CFL1
CREB1
CREBBP
DDAH2
DEPTOR
DLC1
DLG4
EEF1D
EEF2K
ERBIN
ESR1
ETV1
FGFR1
FOS
GBP2
GMFB
GOPC
GORASP1
GORASP2
GRB2
GRID2IP
GSK3B
HTRA1
L1CAM
LIMK2
LNX1
MAGI1
MAGI2
MAGI3
MAPK1
MAPK3
MAPT
MAST1
MAST2
METTL1
MITF
MPP1
MTOR
MXD1
NFKBIA
NHERF2
NR4A1
NR4A2
NR4A3
PARD3B
PDCD4
PDPK1
PDZD7
PDZK1
PDZRN3
PDZRN4
PHAX
POLDIP3
PPM1G
PPP1R3A
PPP1R9A
PTPN3
RPTOR
SHANK3
SHROOM2
SNTA1
SNTB1
SNTG2
SNX27
SRF
SRSF5
STAT3
SYK
SYNJ2BP
TAMALIN
TOB2
TP53
TSC2
TTK
UBE2T
VCP
WHRN
YBX1
YWHAB
Entrez ID
5170
6195
HPRD ID
05556
03402
Ensembl ID
ENSG00000140992
ENSG00000117676
Uniprot IDs
E9PER6
O15530
Q15418
PDB IDs
1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
4CT1
4CT2
4RQK
4RQV
4RRV
4XX9
5ACK
5HKM
5HNG
5HO7
5HO8
5LVL
5LVM
5LVN
5LVO
5LVP
5MRD
6WJQ
8DQT
2WNT
2Z7Q
2Z7R
2Z7S
3RNY
3TEI
4H3P
4NIF
5CSF
5CSI
5CSJ
5CSN
5N7D
5N7F
5N7G
5V61
5V62
6TWY
7P74
7PC8
7QQL
8WF4
8XOV
Enriched GO Terms of Interacting Partners
?
Protein Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Kinase Activity
Protein Phosphorylation
Phosphorylation
Intracellular Signal Transduction
ATP Binding
Protein Modification Process
Cytosol
Cellular Response To Peptide Hormone Stimulus
Nucleotide Binding
Cellular Response To Oxygen-containing Compound
Protein Metabolic Process
Cellular Response To Hormone Stimulus
Cytoplasm
Diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Cellular Response To Insulin Stimulus
Nucleus
TOR Signaling
Transferase Activity
TORC1 Signaling
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Response To Peptide Hormone
Negative Regulation Of Cellular Response To Insulin Stimulus
Response To Hormone
Phosphate-containing Compound Metabolic Process
Signal Transduction
Regulation Of Signal Transduction
Negative Regulation Of TOR Signaling
Regulation Of Generation Of Precursor Metabolites And Energy
Cellular Response To Insulin Stimulus
Peptidyl-serine Phosphorylation
Response To Fluid Shear Stress
Regulation Of TOR Signaling
Regulation Of Signaling
Negative Regulation Of Apoptotic Process
Regulation Of Cell Communication
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Programmed Cell Death
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Signal Transduction
Cellular Response To Fluid Shear Stress
Regulation Of Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Signal Transduction
Intracellular Signaling Cassette
Cytoplasm
Phosphatase Binding
Regulation Of Cell Development
Positive Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
Regulation Of Cellular Component Organization
Nuclear Glucocorticoid Receptor Binding
Regulation Of Cell Population Proliferation
Regulation Of Cell Differentiation
Regulation Of Cellular Response To Heat
Positive Regulation Of Protein-containing Complex Assembly
Cellular Response To Nutrient Levels
TOR Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of TOR Signaling
Regulation Of Multicellular Organismal Process
Cellular Response To Hormone Stimulus
Cellular Response To Peptide Hormone Stimulus
Protein Phosphorylation
Cellular Response To Stress
TORC1 Signaling
Regulation Of TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Developmental Process
Negative Regulation Of Signal Transduction
Regulation Of Osteoclast Differentiation
Response To Peptide Hormone
Regulation Of Multicellular Organismal Development
Negative Regulation Of Autophagy
Response To Decreased Oxygen Levels
Regulation Of TOR Signaling
Negative Regulation Of Catabolic Process
Intracellular Protein Localization
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Organelle Organization
Response To Oxygen Levels
Regulation Of Developmental Process
PDZ Domain Binding
Response To Nutrient Levels
Cellular Response To Cytokine Stimulus
Regulation Of Apoptotic Process
Regulation Of Intracellular Signal Transduction
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Tagcloud (Intersection)
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