PDPK1 and XPO7

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PDPK1	XPO7
Description		3-phosphoinositide dependent protein kinase 1	exportin 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytoplasmic Vesicle Cell Projection Anchoring Junction	Nucleus Nuclear Pore Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Phospholipase Binding Protein Serine Kinase Activity	Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding
	Biological Process	Type B Pancreatic Cell Development Protein Phosphorylation Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Calcium-mediated Signaling Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Intracellular Signaling Cassette Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Nuclear Transport
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Activation of AKT2 Downstream TCR signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated NF-kB activation Integrin signaling CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma RSK activation VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases activate PKNs Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine Bisindolylmaleimide VIII Staurosporine Bisindolylmaleimide I Dexfosfoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE Fostamatinib
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lung cancer in ever smokers ( 28604730) Maximum habitual alcohol consumption ( 31151762) Mean corpuscular hemoglobin ( 28017375 29403010 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 20139978 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) PR interval ( 32439900) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278)
Interacting Genes		68 interacting genes: AKT1 AKT2 AKT3 AKTIP APBB3 APP BLMH CARD11 CDAN1 CSK CSNK1D CUL3 DDIT4 GIT1 GSK3B HSP90AA1 ILK IRS1 ITGB3 KATNBL1 KLHL20 LUC7L2 MAPK8 MTOR NHERF2 PAK1 PEA15 PHAX PIK3C3 PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PRXL2B PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SMARCB1 SOCS3 SPOP SRC SRPK1 STRAP TCAP UBC UBE2I WDCP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133	9 interacting genes: DDX19B MAPK9 NUP153 PDPK1 RAN RNF10 TAB1 USO1 XPOT
Entrez ID		5170	23039
HPRD ID		05556	05846
Ensembl ID		ENSG00000140992	ENSG00000130227
Uniprot IDs		E9PER6 O15530	Q9UIA9
PDB IDs		1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LVM 5LVN 5LVO 5LVP 5MRD 6WJQ 8DQT
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Phosphorylation Phosphorylation Intracellular Signal Transduction ATP Binding Protein Modification Process Cytosol Cellular Response To Peptide Hormone Stimulus Nucleotide Binding Cellular Response To Oxygen-containing Compound Protein Metabolic Process Cellular Response To Hormone Stimulus Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cellular Response To Insulin Stimulus Nucleus TOR Signaling Transferase Activity TORC1 Signaling Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Response To Peptide Hormone Negative Regulation Of Cellular Response To Insulin Stimulus Response To Hormone Phosphate-containing Compound Metabolic Process Signal Transduction Regulation Of Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Insulin Stimulus Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Regulation Of TOR Signaling Regulation Of Signaling Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Fluid Shear Stress Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction	Nuclear Export RNA Export From Nucleus Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Intracellular Transport RNA Transport Cellular Localization Nucleobase-containing Compound Transport Establishment Of Localization In Cell Intracellular Protein Transport Nuclear Inclusion Body Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Protein Localization Protein Transport Nuclear Envelope Regulation Of Glial Cell Proliferation Establishment Of Protein Localization 3-phosphoinositide-dependent Protein Kinase Activity Golgi Vesicle Docking TRNA Re-export From Nucleus RNA Binding Intracellular Signaling Cassette Protein Localization To Tricellular Tight Junction RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Positive Regulation Of Multicellular Organismal Process Regulation Of Gliogenesis JUN Kinase Activity TRNA Export From Nucleus Cytoplasm Cytosol Regulation Of Nucleocytoplasmic Transport Import Into Nucleus Protein Import Into Nucleus RNA Import Into Nucleus POZ Domain Binding Negative Regulation Of RNA Export From Nucleus Viral Penetration Into Host Nucleus MRNA Transport Nuclear Matrix Regulation Of Cellular Localization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Viral Process Ribosomal Large Subunit Export From Nucleus TRNA Transport
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