PDPK1 and AKT2

Number of citations of the paper that reports this interaction (PubMedID 9512493)
45

Data Source:
HPRD (in vivo, in vitro)

		PDPK1	AKT2
Description		3-phosphoinositide dependent protein kinase 1	AKT serine/threonine kinase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytoplasmic Vesicle Cell Projection Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Membrane Ruffle Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Phospholipase Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity
	Biological Process	Type B Pancreatic Cell Development Protein Phosphorylation Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Calcium-mediated Signaling Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Intracellular Signaling Cassette Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Protein Stabilization Regulation Of Cell Cycle Mammary Gland Epithelial Cell Differentiation Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Retinal Rod Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Cell Motility
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Activation of AKT2 Downstream TCR signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated NF-kB activation Integrin signaling CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma RSK activation VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases activate PKNs Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Regulation of MITF-M-dependent genes involved in pigmentation
Drugs		Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine Bisindolylmaleimide VIII Staurosporine Bisindolylmaleimide I Dexfosfoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE Fostamatinib	N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases			Ovarian cancer Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS		Hip circumference adjusted for BMI ( 34021172)	Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte count ( 32888494)
Interacting Genes		68 interacting genes: AKT1 AKT2 AKT3 AKTIP APBB3 APP BLMH CARD11 CDAN1 CSK CSNK1D CUL3 DDIT4 GIT1 GSK3B HSP90AA1 ILK IRS1 ITGB3 KATNBL1 KLHL20 LUC7L2 MAPK8 MTOR NHERF2 PAK1 PEA15 PHAX PIK3C3 PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PRXL2B PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SMARCB1 SOCS3 SPOP SRC SRPK1 STRAP TCAP UBC UBE2I WDCP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133	43 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP
Entrez ID		5170	208
HPRD ID		05556	01262
Ensembl ID		ENSG00000140992	ENSG00000105221
Uniprot IDs		E9PER6 O15530	B4DG79 P31751
PDB IDs		1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LVM 5LVN 5LVO 5LVP 5MRD 6WJQ 8DQT	1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D 8Q61 9C1W
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Phosphorylation Phosphorylation Intracellular Signal Transduction ATP Binding Protein Modification Process Cytosol Cellular Response To Peptide Hormone Stimulus Nucleotide Binding Cellular Response To Oxygen-containing Compound Protein Metabolic Process Cellular Response To Hormone Stimulus Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cellular Response To Insulin Stimulus Nucleus TOR Signaling Transferase Activity TORC1 Signaling Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Response To Peptide Hormone Negative Regulation Of Cellular Response To Insulin Stimulus Response To Hormone Phosphate-containing Compound Metabolic Process Signal Transduction Regulation Of Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Insulin Stimulus Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Regulation Of TOR Signaling Regulation Of Signaling Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Fluid Shear Stress Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction	Intracellular Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Hormone Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Nitric-oxide Synthase Regulator Activity Intracellular Signaling Cassette Regulation Of Innate Immune Response Cytosol Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Hormone Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Response To Insulin Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Chemical Homeostasis Low-density Lipoprotein Particle Regulation Of Vesicle-mediated Transport Cellular Response To Oxygen-containing Compound Cellular Response To Amyloid-beta Homeostatic Process Response To Peptide Hormone Endocytic Vesicle Lumen Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Catabolic Process Protein Kinase Binding Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Response To Amyloid-beta Regulation Of Immune System Process Response To Stress Positive Regulation Of Signal Transduction Regulation Of Nitric Oxide Metabolic Process Response To Nutrient Levels Regulation Of Protein Modification Process Protein Serine/threonine Kinase Binding Cholesterol Transfer Activity Regulation Of Defense Response
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