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SOS2 and PLCG1
Number of citations of the paper that reports this interaction (PubMedID
10940929
)
0
Data Source:
HPRD
(two hybrid, in vivo)
SOS2
PLCG1
Description
SOS Ras/Rho guanine nucleotide exchange factor 2
phospholipase C gamma 1
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
COP9 Signalosome
Lamellipodium
Ruffle Membrane
Cell Projection
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Heterodimerization Activity
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Phospholipase C Activity
Guanyl-nucleotide Exchange Factor Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Phosphoric Diester Hydrolase Activity
Hydrolase Activity
Protein Kinase Binding
Metal Ion Binding
Calcium-dependent Phospholipase C Activity
Phosphatidylinositol Phospholipase C Activity
Biological Process
B Cell Homeostasis
Lymphocyte Homeostasis
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of T Cell Differentiation In Thymus
Regulation Of T Cell Proliferation
Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Lipid Metabolic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Lipid Catabolic Process
Cell Migration
Calcium-mediated Signaling
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Phosphatidylinositol-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Sequestering Of Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
Activation of RAC1
Interleukin-15 signaling
RAC1 GTPase cycle
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Signaling by ALK
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS
Birth weight (
31043758
)
Erythema nodosum in inflammatory bowel disease (
24487271
)
Estimated glomerular filtration rate (
31015462
)
Hemoglobin (
32888494
)
Intraocular pressure (
29617998
29785010
30054594
31959993
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Medication use (calcium channel blockers) (
31015401
)
Medication use (diuretics) (
31015401
)
Periodontal disease-related phenotype (Socransky) (
24347629
)
Pulse pressure (
30578418
)
Red blood cell count (
32888494
)
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
20 interacting genes:
ABI1
ABL1
BIN1
CD2AP
CREBBP
CRKL
DSCAM
EGFR
GRAP2
GRB2
HRAS
ITSN1
ITSN2
PACSIN3
PLCG1
SH3D19
SHC1
SNX18
SNX9
UBASH3A
112 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RBM11
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
Entrez ID
6655
5335
HPRD ID
03149
01398
Ensembl ID
ENSG00000100485
ENSG00000124181
Uniprot IDs
Q07890
P19174
PDB IDs
6EIE
8T5G
8T5M
8T5R
8UC9
8UF2
8UH0
9BVE
9BVF
9BVI
9GIN
1HSQ
2HSP
4EY0
4FBN
7NXE
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Endocytosis
Phosphotyrosine Residue Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Import Into Cell
Enzyme-linked Receptor Protein Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
ERBB Signaling Pathway
Neurotrophin TRKA Receptor Binding
Immune Response-activating Signaling Pathway
T Cell Receptor Signaling Pathway
Intracellular Signaling Cassette
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Cellular Component Organization
Plasma Membrane Tubulation
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Plasma Membrane
Intracellular Signal Transduction
Response To Growth Factor
Cytosol
Proline-rich Region Binding
Lipid Tube Assembly
Shc-EGFR Complex
Clathrin-dependent Synaptic Vesicle Endocytosis
Intracellular Vesicle
Regulation Of Actin Cytoskeleton Organization
Ras Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Vesicle-mediated Transport
Cell Surface Receptor Signaling Pathway
Regulation Of Actin Filament-based Process
Regulation Of Membrane Protein Ectodomain Proteolysis
Ephrin Receptor Binding
MAPK Cascade
Regulation Of MAPK Cascade
Regulation Of Immune Response
Ruffle
Positive Regulation Of Immune Response
Cytoplasm
Epidermal Growth Factor Binding
Small GTPase-mediated Signal Transduction
Synaptic Vesicle Endocytosis
Cellular Response To Growth Factor Stimulus
Endosome
Regulation Of ERK1 And ERK2 Cascade
Presynaptic Endocytosis
Positive Regulation Of Cellular Component Biogenesis
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Activity
Plasma Membrane
Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Phosphorylation
Regulation Of Signal Transduction
Protein Autophosphorylation
Positive Regulation Of Signal Transduction
Cell Migration
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Receptor Complex
Antigen Receptor-mediated Signaling Pathway
Cell Motility
Activation Of Immune Response
Immune System Process
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Population Proliferation
Fc Receptor Signaling Pathway
ATP Binding
Cell Activation
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Population Proliferation
Response To Growth Factor
Developmental Process
Nucleotide Binding
Leukocyte Activation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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