SOS2 and SH3D19

Number of citations of the paper that reports this interaction (PMID 14551139)
5

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SOS2	SH3D19
Gene Name		son of sevenless homolog 2 (Drosophila)	SH3 domain containing 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	DNA Binding Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Proline-rich Region Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Post-Golgi Vesicle-mediated Transport Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Membrane Organization
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling Activation of Rac NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Signaling by Robo receptor	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9	11 interactors: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3YL1 SOS2
Entrez ID		6655	152503
HPRD ID		03149	16364
Ensembl ID		ENSG00000100485	ENSG00000109686
Uniprot IDs		B7ZKT6 Q07890	Q5HYK7
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytosis Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Immune Response Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Activation Of MAPKK Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Hydrolase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Ras Protein Signal Transduction Positive Regulation Of MAPK Cascade Lipid Tube Assembly Cell Migration Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway	PMA-inducible Membrane Protein Ectodomain Proteolysis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Collagen Metabolic Process Membrane Protein Ectodomain Proteolysis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Protein Proteolysis Anatomical Structure Development Signal Transduction Developmental Process Monocyte Activation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Signaling Regulation Of Cellular Component Organization Cell Communication System Development Regulation Of ERBB Signaling Pathway Positive Regulation Of T Cell Chemotaxis Cell Morphogenesis Involved In Differentiation Cell Surface Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell Differentiation Axon Guidance Integrin-mediated Signaling Pathway Cellular Response To Stimulus Anatomical Structure Morphogenesis Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Notch Receptor Processing Cell Morphogenesis Response To External Stimulus Axonogenesis Regulation Of Lymphocyte Migration Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Wound Healing Chemotaxis
Tagcloud ?		arnt bio biogrid bmpr1b crebl dijkstra ecm etc greedy hsc hscs integrative iterative kegg map2k1 nf1 pik3r3 ppp2r1a prkca searching smad2 stellate targetome tfs tranfac transcriptome transcriptomic uncovered underlie
Tagcloud (Difference) ?		arnt bio biogrid bmpr1b crebl dijkstra ecm etc greedy hsc hscs integrative iterative kegg map2k1 nf1 pik3r3 ppp2r1a prkca searching smad2 stellate targetome tfs tranfac transcriptome transcriptomic uncovered underlie
Tagcloud (Intersection) ?