SOS2 and SNX18

Number of citations of the paper that reports this interaction (PMID 14679214)
56

Data Source:
HPRD (in vitro)

		SOS2	SNX18
Gene Name		son of sevenless homolog 2 (Drosophila)	sorting nexin 18
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Endosome Endosome Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Mitotic Nuclear Division Vesicle Organization Endosomal Transport Cleavage Furrow Formation Positive Regulation Of GTPase Activity
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling Activation of Rac NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Signaling by Robo receptor
Drugs
Diseases
GWAS			Immune response to smallpox vaccine (IL-6) ( 22542470)
Protein-Protein Interactions		16 interactors: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9	2 interactors: SOS1 SOS2
Entrez ID		6655	112574
HPRD ID		03149	15407
Ensembl ID		ENSG00000100485	ENSG00000178996
Uniprot IDs		B7ZKT6 Q07890	Q96RF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytosis Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Immune Response Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Activation Of MAPKK Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Hydrolase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Ras Protein Signal Transduction Positive Regulation Of MAPK Cascade Lipid Tube Assembly Cell Migration Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway	Positive Regulation Of Small GTPase Mediated Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Axon Guidance Positive Regulation Of Ras GTPase Activity Axonogenesis Regulation Of Ras GTPase Activity Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Chemotaxis Positive Regulation Of Cell Death Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Development Apoptotic Process Programmed Cell Death Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Death Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Positive Regulation Of Signal Transduction Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Regulation Of Cell Death Generation Of Neurons
Tagcloud ?		arnt bio biogrid bmpr1b crebl dijkstra ecm etc greedy hsc hscs integrative iterative kegg map2k1 nf1 pik3r3 ppp2r1a prkca searching smad2 stellate targetome tfs tranfac transcriptome transcriptomic uncovered underlie	atrophin beyond bind containing e3 endocytic extends interacting itch ligase ligases motifs nedd4 nexin pool possess prd proline py sh3 snx9 sorting substrates truncated ubiquitin ubiquitylates ubiquitylation ww
Tagcloud (Difference) ?		arnt bio biogrid bmpr1b crebl dijkstra ecm etc greedy hsc hscs integrative iterative kegg map2k1 nf1 pik3r3 ppp2r1a prkca searching smad2 stellate targetome tfs tranfac transcriptome transcriptomic uncovered underlie	atrophin beyond bind containing e3 endocytic extends interacting itch ligase ligases motifs nedd4 nexin pool possess prd proline py sh3 snx9 sorting substrates truncated ubiquitin ubiquitylates ubiquitylation ww
Tagcloud (Intersection) ?