SOS2 and PACSIN3

Number of citations of the paper that reports this interaction (PubMedID 14679214)
0

Data Source:
HPRD (in vitro, in vivo)

		SOS2	PACSIN3
Description		SOS Ras/Rho guanine nucleotide exchange factor 2	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding
	Biological Process	B Cell Homeostasis Lymphocyte Homeostasis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Regulation Of Pro-B Cell Differentiation	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling RAC1 GTPase cycle	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 30054594 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		20 interacting genes: ABI1 ABL1 BIN1 CD2AP CREBBP CRKL DSCAM EGFR GRAP2 GRB2 HRAS ITSN1 ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9 UBASH3A	24 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 OGT PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL
Entrez ID		6655	29763
HPRD ID		03149	05937
Ensembl ID		ENSG00000100485	ENSG00000165912
Uniprot IDs		Q07890	Q9UKS6
PDB IDs		6EIE 8T5G 8T5M 8T5R 8UC9 8UF2 8UH0 9BVE 9BVF 9BVI 9GIN
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cellular Component Organization Plasma Membrane Tubulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Plasma Membrane Intracellular Signal Transduction Response To Growth Factor Cytosol Proline-rich Region Binding Lipid Tube Assembly Shc-EGFR Complex Clathrin-dependent Synaptic Vesicle Endocytosis Intracellular Vesicle Regulation Of Actin Cytoskeleton Organization Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Membrane Protein Ectodomain Proteolysis Ephrin Receptor Binding MAPK Cascade Regulation Of MAPK Cascade Regulation Of Immune Response Ruffle Positive Regulation Of Immune Response Cytoplasm Epidermal Growth Factor Binding Small GTPase-mediated Signal Transduction Synaptic Vesicle Endocytosis Cellular Response To Growth Factor Stimulus Endosome Regulation Of ERK1 And ERK2 Cascade Presynaptic Endocytosis Positive Regulation Of Cellular Component Biogenesis	Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Plasma Membrane Ruffle Membrane Synaptic Vesicle Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Presynaptic Endocytosis Regulation Of Pro-B Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Glutamatergic Synapse Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of T Cell Differentiation Import Into Cell Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane Tubulation Regulation Of Plasma Membrane Organization Cell Projection Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Differentiation Vesicle-mediated Transport In Synapse Schwann Cell Development Endocytosis Protein Kinase Binding Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Protein Localization SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus Establishment Of Organelle Localization Cytoplasmic Vesicle Vesicle Budding From Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Clathrin Coat Assembly Involved In Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Organization Regulation Of Endocytosis Regulation Of Lymphocyte Activation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway B Cell Homeostasis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation
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