SOS2 and PACSIN3

Number of citations of the paper that reports this interaction (PMID 14679214)
56

Data Source:
HPRD (in vitro, in vivo)

		SOS2	PACSIN3
Gene Name		son of sevenless homolog 2 (Drosophila)	protein kinase C and casein kinase substrate in neurons 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Endosome Plasma Membrane Membrane Membrane-bounded Vesicle Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Membrane Tubulation
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling Activation of Rac NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9	18 interactors: ADAM12 ADAM15 ASAP1 ASAP2 DNM1 ITSN1 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TRPV4 WASL
Entrez ID		6655	29763
HPRD ID		03149	05937
Ensembl ID		ENSG00000100485	ENSG00000165912
Uniprot IDs		B7ZKT6 Q07890	Q9UKS6
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytosis Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Immune Response Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Activation Of MAPKK Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Hydrolase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Ras Protein Signal Transduction Positive Regulation Of MAPK Cascade Lipid Tube Assembly Cell Migration Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway	Cell Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Development Regulation Of Ras Protein Signal Transduction Anatomical Structure Development Cell Differentiation Generation Of Neurons Regulation Of Small GTPase Mediated Signal Transduction Neuron Differentiation Neurogenesis Developmental Process Regulation Of Ras GTPase Activity Synaptic Vesicle Endocytosis Cell Development Synaptic Vesicle Recycling Establishment Of Organelle Localization Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Endocytosis Organelle Localization Establishment Of Vesicle Localization Nervous System Development Regulation Of GTPase Activity Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Regulation Of Signaling Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway
Tagcloud ?		arnt bio biogrid bmpr1b crebl dijkstra ecm etc greedy hsc hscs integrative iterative kegg map2k1 nf1 pik3r3 ppp2r1a prkca searching smad2 stellate targetome tfs tranfac transcriptome transcriptomic uncovered underlie
Tagcloud (Difference) ?		arnt bio biogrid bmpr1b crebl dijkstra ecm etc greedy hsc hscs integrative iterative kegg map2k1 nf1 pik3r3 ppp2r1a prkca searching smad2 stellate targetome tfs tranfac transcriptome transcriptomic uncovered underlie
Tagcloud (Intersection) ?