NME4 and SOCS3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NME4	SOCS3
Gene Name		NME/NM23 nucleoside diphosphate kinase 4	suppressor of cytokine signaling 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol	Cytoplasm Cytosol
	Molecular Function	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Protein Complex Binding Metal Ion Binding	Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Nucleoside Metabolic Process Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Regulation Of Apoptotic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin
Drugs
Diseases
GWAS		Red blood cell traits ( 23446634)	Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		7 interactors: LSM8 NME1 NME1-NME2 NME2 SOCS3 SUV39H2 TRIP13	48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1
Entrez ID		4833	9021
HPRD ID		03489	05006
Ensembl ID		ENSG00000103202	ENSG00000184557
Uniprot IDs		A2IDD0 O00746	O14543 Q6FI39
PDB IDs		1EHW
Enriched GO Terms of Interacting Partners?		GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Purine Nucleoside Metabolic Process Response To Testosterone Cell Differentiation Ribonucleotide Metabolic Process Nucleoside Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Cellular Response To Fatty Acid Ribose Phosphate Metabolic Process Response To Amine Negative Regulation Of Myeloid Leukocyte Differentiation Cellular Response To Drug Male Meiosis Cellular Response To Glucose Stimulus Response To Fatty Acid Hippocampus Development Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Negative Regulation Of Myeloid Cell Differentiation Nucleobase-containing Compound Metabolic Process Limbic System Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleotide Metabolic Process Regulation Of Myeloid Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Response To CAMP Response To Glucose Nucleobase-containing Small Molecule Metabolic Process Response To Organophosphorus Positive Regulation Of Epithelial Cell Proliferation Developmental Process Nitrogen Compound Metabolic Process	Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process
Tagcloud ?		5q aml analysed array arrays blast cdna cluster comprising de differently ercc1 flt1 larger myelodysplastic novo pcna probes profiles progressive qrt raeb rcmd represents subtypes transformation unfavorable validated whose	activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer
Tagcloud (Difference) ?		5q aml analysed array arrays blast cdna cluster comprising de differently ercc1 flt1 larger myelodysplastic novo pcna probes profiles progressive qrt raeb rcmd represents subtypes transformation unfavorable validated whose	activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer
Tagcloud (Intersection) ?