SHC1 and DDR1

Number of citations: 0 (PubMedID 10783152)
Data Source: HPRD (in vitro, in vivo)

		SHC1	DDR1
Name		SHC adaptor protein 1	discoidin domain receptor tyrosine kinase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Focal Adhesion Anchoring Junction Shc-EGFR Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Receptor Tyrosine Kinase Binding Ephrin Receptor Binding Epidermal Growth Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cell Population Proliferation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Regulation Of Superoxide Metabolic Process Cell-cell Adhesion	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Female Pregnancy Embryo Implantation Lactation Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Neuron Projection Development Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension
Pathways		Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells	Non-integrin membrane-ECM interactions
Drugs		None	Imatinib Fostamatinib Pralsetinib
GWAS		Bipolar disorder ( 31043756 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Eosinophil count ( 29403010 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 27569725 ) Prostate cancer ( 23535732 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Age-related macular degeneration ( 23455636 ) Arterial stiffness index ( 31235810 ) Autism spectrum disorder or schizophrenia ( 28540026 ) HIV-1 control ( 20041166 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Malaria ( 31844061 ) Microalbuminuria in type 1 diabetes ( 31537649 ) Response to hepatitis B vaccine ( 29534301 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Schizophrenia ( 30285260 ) Serum alkaline phosphatase levels ( 33547301 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Takayasu arteritis ( 25604533 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Ulcerative colitis ( 20848476 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		144 interacting genes: ALK AP2A1 AP2A2 APP AR AXL BCL3 BCR BUB1 C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CFTR CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FBXW7 FCGR2A FCGR3A FGFR1 FGFR2 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KIT KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLPP3 PLSCR1 PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RB1 RET SH2B2 SHCBP1 SMAD4 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR TRIM15 UBASH3B VAV1 VAV3 ZAP70	20 interacting genes: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NOTCH1 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2
Entrez ID		6464	780
HPRD ID		02780	02678
Ensembl ID		ENSG00000160691	ENSG00000204580
Uniprot IDs		P29353	A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62
PDB IDs		1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 2L1C 4JMH 4XWX 5CZI 6DM4	3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 5SAU 5SAV 5SAW 5SAX 5SAY 5SAZ 5SB0 5SB1 5SB2 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6 7FEH 8PE9
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Receptor Complex Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Plasma Membrane Positive Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Phosphorylation Phosphotyrosine Residue Binding Intracellular Signal Transduction Regulation Of Developmental Process Protein Autophosphorylation Immune System Process Regulation Of Immune Response Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Intracellular Signaling Cassette Response To Growth Factor Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Cell Motility	Fibrillar Collagen Trimer Collagen Type XI Trimer Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To Growth Factor Stimulus Collagen Fibril Organization Receptor Tyrosine Kinase Binding Response To Growth Factor Collagen Trimer Anatomical Structure Formation Involved In Morphogenesis Collagen Type II Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Anatomical Structure Homeostasis Tissue Homeostasis Platelet-derived Growth Factor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Muscle Cell Differentiation Muscle Tissue Morphogenesis Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Developmental Process Cartilage Condensation Cartilage Development Positive Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Regulation Of Cell-cell Adhesion Cell Aggregation Signal Transduction Negative Regulation Of Multicellular Organismal Process Prostate Gland Epithelium Morphogenesis Insulin Receptor Binding Positive Regulation Of Signal Transduction